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透明质酸凝胶注射治疗泪槽畸形:一项多中心、观察性、单盲研究。

Hyaluronic Acid Gel Injection for the Treatment of Tear Trough Deformity: A Multicenter, Observational, Single-Blind Study.

机构信息

Rigeneralab Centre for Regenerative Medicine, Corso Unione Sovietica 159/a, 10134, Turin, Italy.

, Cagliari, Italy.

出版信息

Aesthetic Plast Surg. 2022 Aug;46(4):1860-1867. doi: 10.1007/s00266-022-02887-7. Epub 2022 Apr 27.

Abstract

BACKGROUND

Hyaluronic acid (HA) gel injections were first used to treat the tear trough in 2005 and since then it has been a mainstay of the approach to lower eyelid deformities.

OBJECTIVE

The authors present this retrospective multicentric observational study based on single-blind objective and subjective evaluation and patient satisfaction in relation to the aesthetic improvement of a large group of patients treated.

METHODS AND MATERIALS

Between January 2016 and December 2019, 600 patients (468 women and 132 men), were enrolled in this study, and 1200 tear trough deformities were treated with both needle and cannula techniques.

RESULTS

Average follow-up time was 12 ± 1 months, and the outcomes were assessed both objectively and subjectively with respect to Hirmand's classification. Statistical analysis shows an inverse correlation between age and class amelioration.

CONCLUSION

HA injection of the tear trough is most effective in patients between 30 and 40 years of age, while its benefits extend to up to 50 years old; afterward, it should no longer be the treatment of choice. This confirms that correction of tear trough with hyaluronic acid injections may provide an option to achieve immediate and durable results for up to one year after the injection.

LEVEL OF EVIDENCE IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

摘要

背景

透明质酸(HA)凝胶注射于 2005 年首次用于治疗泪槽,此后一直是治疗下眼睑畸形的主要方法。

目的

作者提出了这项回顾性多中心观察性研究,基于对大量治疗患者的美学改善的单盲客观和主观评估以及患者满意度。

方法和材料

2016 年 1 月至 2019 年 12 月,共纳入 600 名患者(468 名女性和 132 名男性),采用针和套管技术治疗 1200 例泪槽畸形。

结果

平均随访时间为 12±1 个月,根据 Hirmand 分类对结果进行客观和主观评估。统计分析显示年龄与改善等级呈负相关。

结论

HA 注射治疗泪槽在 30 至 40 岁患者中最有效,而其益处可延伸至 50 岁;之后,它不应再是治疗的首选。这证实了透明质酸注射矫正泪槽可以提供一种选择,在注射后长达一年的时间内获得即时和持久的效果。

证据等级 IV:本杂志要求作者为每篇文章分配一个证据等级。有关这些循证医学评级的完整描述,请参阅目录或在线作者指南 www.springer.com/00266

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