Cai Yizuo, Jia Zhuoxuan, Gu Jiancheng, Kang Bijun, Li Wei, Zhang Wenjie
Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, National Tissue Engineering Center of China, Shanghai, China.
Division of Plastic Surgery, Shanghai Basilica Clinic, Shanghai, China.
J Cosmet Dermatol. 2025 Feb;24(2):e16682. doi: 10.1111/jocd.16682. Epub 2024 Dec 8.
CEFFE (Cell-free fat extract) treatment for periocular fine lines requires thorough clinical evaluation to determine its efficacy and safety in enhancing skin quality. The research enrolled 10 healthy female participants aged 31-58, focusing on skin texture, elasticity, and barrier function.
CEFFE treatment demonstrated significant benefits, with notable improvements observed as early as 3 months posttreatment, which continued throughout the 12-month follow-up period. Objective assessments revealed reductions in SEr% and SEw%, indicative of reduced skin roughness and wrinkles, particularly pronounced after the third month of treatment. Enhanced skin elasticity, as indicated by improvements in R2%, R5%, and R7%, was observed, with the most significant enhancements noted at the 6-month follow-up. Furthermore, TEWL decreased consistently, highlighting CEFFE's potential in maintaining the skin's barrier function and moisture retention. High patient satisfaction levels, with 70% expressing satisfaction ranging from satisfied to very satisfied, underscored CEFFE's clinical significance.
CEFFE demonstrates potential as an effective and safe intervention for addressing periocular fine lines, providing a solution for fine lines while ensuring skin health (ChiCTR1900024329).
无细胞脂肪提取物（CEFFE）治疗眼周细纹需要进行全面的临床评估，以确定其在改善皮肤质量方面的疗效和安全性。该研究招募了10名年龄在31 - 58岁的健康女性参与者，重点关注皮肤质地、弹性和屏障功能。
CEFFE治疗显示出显著效果，早在治疗后3个月就观察到明显改善，并在整个12个月的随访期内持续存在。客观评估显示，SEr%和SEw%降低，表明皮肤粗糙度和皱纹减少，在治疗第三个月后尤为明显。观察到R2%、R5%和R7%有所改善，表明皮肤弹性增强，在6个月随访时改善最为显著。此外，经皮水分流失（TEWL）持续下降，突出了CEFFE在维持皮肤屏障功能和水分保持方面的潜力。患者满意度较高，70%的患者表示满意程度从满意到非常满意，强调了CEFFE的临床意义。
CEFFE显示出作为一种有效且安全的干预措施来解决眼周细纹的潜力，在确保皮肤健康的同时为细纹提供了解决方案（ChiCTR1900024329）。
