预防季节性 H3N2 流感发病的免疫学相关性。
Immunological Correlates of Prevention of the Onset of Seasonal H3N2 Influenza.
机构信息
Department of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
出版信息
J Infect Dis. 2022 Nov 11;226(10):1800-1808. doi: 10.1093/infdis/jiac152.
On influenza virus infection or vaccination, immune responses occur, including the production of antibodies with various functions that contribute to protection from seasonal influenza virus infection. In the current study, we attempted to identify the antibody functions that play a central role in preventing the onset of seasonal influenza by comparing the levels of several antibody titers for different antibody functions between 5 subclinically infected individuals and 16 patients infected with seasonal H3N2 virus. For antibody titers before influenza virus exposure, we found that the nAb titers and enzyme-linked immunosorbent assay titers against hemagglutinin and neuraminidase (NA) proteins in the subclinically infected individuals were significantly higher than those in the patients, whereas the NA inhibition titers and antibody-dependent cellular cytotoxicity activities did not significantly differ between subclinically infected individuals and infected patients. These results suggest that nAb and enzyme-linked immunosorbent assay titers against hemagglutinin and NA serve as correlates of symptomatic influenza infection.
在流感病毒感染或接种疫苗后，会产生免疫反应，包括产生具有多种功能的抗体，有助于预防季节性流感病毒感染。在本研究中，我们试图通过比较 5 名亚临床感染个体和 16 名感染季节性 H3N2 病毒患者的几种不同抗体功能的抗体滴度，来确定在预防季节性流感中起核心作用的抗体功能。对于流感病毒暴露前的抗体滴度，我们发现亚临床感染个体的中和抗体滴度和针对血凝素和神经氨酸酶（NA）蛋白的酶联免疫吸附试验滴度明显高于感染患者，而 NA 抑制滴度和抗体依赖性细胞毒性活性在亚临床感染个体和感染患者之间没有显著差异。这些结果表明，针对血凝素和 NA 的中和抗体滴度和酶联免疫吸附试验滴度可作为有症状流感感染的相关指标。
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