抗高血压药物组合可减轻顺铂诱导的急性肾损伤。
Antihypertensive Drug Combinations Modify Cisplatin-induced Acute Kidney Injury.
机构信息
Department of Pharmacy, Saga University Hospital, Saga, Japan.
出版信息
In Vivo. 2022 May-Jun;36(3):1391-1396. doi: 10.21873/invivo.12843.
Abstract
BACKGROUND/AIM: There is limited evidence about the nephrotoxicity of calcium channel blockers (CCBs) and renin-angiotensin system (RAS) inhibitors with concomitant cisplatin (CDDP). We investigated whether combinations of antihypertensive drugs are associated with CDDP-related acute kidney injury (AKI) using the Japanese Adverse Drug Event Report database.
PATIENTS AND METHODS
We analysed 544,864 reports in the database from 2004 to 2020. A reporting odds ratio (ROR) and confidence interval (CI) with adjustment for potential confounding factors was calculated for AKI for each drug and the combined use of the drugs and CDDP.
RESULTS
CDDP, CCBs, and RAS inhibitors were all detected signals for AKI. The ROR in cases with concomitant use of CCBs, RAS inhibitors, and CDDP (adjusted ROR 7.28; 95% CI=5.56-9.54) was higher than that in cases with use of each drug.
CONCLUSION
AKI may require more attention when patients receiving CDDP take CCBs and RAS inhibitors together.
摘要
背景/目的：关于钙通道阻滞剂（CCBs）和肾素-血管紧张素系统（RAS）抑制剂与顺铂（CDDP）同时使用的肾毒性的证据有限。我们使用日本药物不良反应报告数据库研究了降压药物联合使用是否与 CDDP 相关的急性肾损伤（AKI）有关。
患者和方法
我们分析了 2004 年至 2020 年数据库中的 544864 份报告。为每种药物和药物与 CDDP 联合使用的 AKI 计算了报告比值比（ROR）和置信区间（CI），并进行了潜在混杂因素的调整。
结果
CDDP、CCBs 和 RAS 抑制剂均为 AKI 的信号。同时使用 CCBs、RAS 抑制剂和 CDDP 的情况下的 ROR（调整后的 ROR 为 7.28；95%CI=5.56-9.54）高于每种药物单独使用的情况。
结论
当接受 CDDP 治疗的患者同时使用 CCBs 和 RAS 抑制剂时，可能需要更加注意 AKI。
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