• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Addressing drug safety of maternal therapy during breastfeeding using physiologically-based pharmacokinetic modeling.

作者信息

Pan Xian, Rowland Yeo Karen

机构信息

Simcyp Division, Certara UK Limited, Sheffield, UK.

出版信息

CPT Pharmacometrics Syst Pharmacol. 2022 May;11(5):535-539. doi: 10.1002/psp4.12802. Epub 2022 Apr 28.

DOI:10.1002/psp4.12802
PMID:35478449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9124349/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cab/9124349/5e28509131f0/PSP4-11-535-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cab/9124349/d8a4248fe04f/PSP4-11-535-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cab/9124349/5e28509131f0/PSP4-11-535-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cab/9124349/d8a4248fe04f/PSP4-11-535-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cab/9124349/5e28509131f0/PSP4-11-535-g001.jpg

相似文献

1
Addressing drug safety of maternal therapy during breastfeeding using physiologically-based pharmacokinetic modeling.利用基于生理的药代动力学模型解决母乳喂养期间母体治疗的药物安全性问题。
CPT Pharmacometrics Syst Pharmacol. 2022 May;11(5):535-539. doi: 10.1002/psp4.12802. Epub 2022 Apr 28.
2
Quantifying breast milk intake by term and preterm infants for input into paediatric physiologically based pharmacokinetic models.定量测量足月和早产儿的母乳摄入量，以输入儿科生理基于药代动力学模型。
Matern Child Nutr. 2020 Apr;16(2):e12938. doi: 10.1111/mcn.12938. Epub 2020 Jan 21.
3
State-of-the-Art Review on Physiologically Based Pharmacokinetic Modeling in Pediatric Drug Development.儿科药物开发中基于生理的药代动力学建模的最新技术综述。
Clin Pharmacokinet. 2019 Jan;58(1):1-13. doi: 10.1007/s40262-018-0677-y.
4
Industry Perspective of Drug Development for Pregnant/Breastfeeding Women.孕期/哺乳期女性药物研发的行业视角
Clin Pharmacol Ther. 2016 Jul;100(1):19-21. doi: 10.1002/cpt.381. Epub 2016 May 9.
5
Mother-to-child transmission of HIV: implications of variation in maternal infectivity.艾滋病病毒的母婴传播：母亲传染性差异的影响
AIDS. 1998 Nov 12;12(16):2211-6. doi: 10.1097/00002030-199816000-00017.
6
Clinical lactation studies and the role of pharmacokinetic modeling and simulation in predicting drug exposures in breastfed infants.临床哺乳研究以及药代动力学建模和模拟在预测母乳喂养婴儿药物暴露中的作用。
J Pharmacokinet Pharmacodyn. 2020 Aug;47(4):295-304. doi: 10.1007/s10928-020-09676-2. Epub 2020 Feb 7.
7
Physiologically based pharmacokinetic (PBPK) modeling and simulation in neonatal drug development: how clinicians can contribute.生理药代动力学（PBPK）模型在新生儿药物研发中的应用和模拟：临床医生如何贡献力量。
Expert Opin Drug Metab Toxicol. 2019 Jan;15(1):25-34. doi: 10.1080/17425255.2019.1558205. Epub 2018 Dec 17.
8
Physiologically based pharmacokinetic modeling of persistent organic pollutants for lifetime exposure assessment: a new tool in breast cancer epidemiologic studies.用于终生暴露评估的持久性有机污染物基于生理学的药代动力学建模：乳腺癌流行病学研究中的一种新工具。
Environ Health Perspect. 2008 Jul;116(7):886-92. doi: 10.1289/ehp.10917.
9
Evaluation of the effectiveness of a structured breast-feeding promotion program integrated into a Maternal and Child Health service in Jerusalem.对耶路撒冷母婴健康服务中纳入的结构化母乳喂养促进项目的效果评估。
Isr J Med Sci. 1988 Jul;24(7):342-8.
10
Using Physiologically Based Pharmacokinetic Modeling for Mechanistic Insight: Cases of Reverse Translation.使用基于生理的药代动力学模型进行机理洞察：反向翻译案例
Clin Transl Sci. 2018 Mar;11(2):109-111. doi: 10.1111/cts.12517. Epub 2017 Oct 30.

引用本文的文献

1
Transcutaneous Auricular Vagus Nerve Stimulation for Postpartum Contraction Pain During Elective Cesarean Delivery: A Randomized Clinical Trial.择期剖宫产术中经皮耳迷走神经刺激用于产后宫缩痛：一项随机临床试验
JAMA Netw Open. 2025 Aug 1;8(8):e2529127. doi: 10.1001/jamanetworkopen.2025.29127.
2
Pharmacokinetics of Ivacaftor, Tezacaftor, Elexacaftor, and Lumacaftor in Special Cystic Fibrosis Populations: A Systematic Review.依伐卡托、替扎卡托、艾列卡托和鲁马卡托在特殊囊性纤维化人群中的药代动力学：一项系统评价。
Clin Pharmacokinet. 2025 May 21. doi: 10.1007/s40262-025-01507-2.
3
Informing the risk assessment related to lactation and drug exposure: A physiologically based pharmacokinetic lactation model for pregabalin.

本文引用的文献

1
Increasing application of pediatric physiologically based pharmacokinetic models across academic and industry organizations.儿科生理基于药代动力学模型在学术和行业组织中的应用不断增加。
CPT Pharmacometrics Syst Pharmacol. 2022 Mar;11(3):373-383. doi: 10.1002/psp4.12764. Epub 2022 Feb 17.
2
Physiologically Based Pharmacokinetics Model in Pregnancy: A Regulatory Perspective on Model Evaluation.孕期基于生理的药代动力学模型：模型评估的监管视角
Front Pediatr. 2021 Jun 23;9:687978. doi: 10.3389/fped.2021.687978. eCollection 2021.
3
Prediction of drug concentrations in milk during breastfeeding, integrating predictive algorithms within a physiologically-based pharmacokinetic model.
在哺乳期和药物暴露相关的风险评估中：普瑞巴林的基于生理的药代动力学哺乳模型。
CPT Pharmacometrics Syst Pharmacol. 2024 Nov;13(11):1953-1966. doi: 10.1002/psp4.13266. Epub 2024 Oct 26.
4
EMA perspective on the value of model-informed drug development for labeling recommendations regarding medicine use during pregnancy and breastfeeding.欧洲药品管理局对模型辅助药物研发在孕期和哺乳期用药标签建议方面价值的观点。
CPT Pharmacometrics Syst Pharmacol. 2024 Nov;13(11):1820-1823. doi: 10.1002/psp4.13214. Epub 2024 Aug 13.
5
Supplementing clinical lactation studies with PBPK modeling to inform drug therapy in lactating mothers: Prediction of primaquine exposure as a case example.用 PBPK 模型补充临床哺乳研究，为哺乳期母亲的药物治疗提供信息：以磷酸伯氨喹为例进行预测。
CPT Pharmacometrics Syst Pharmacol. 2024 Mar;13(3):386-395. doi: 10.1002/psp4.13090. Epub 2023 Dec 12.
6
Total and Free Blood and Plasma Concentration Changes in Pregnancy for Medicines Highly Bound to Plasma Proteins: Application of Physiologically Based Pharmacokinetic Modelling to Understand the Impact on Efficacy.血浆蛋白高度结合药物在孕期的总血药浓度及游离血药浓度和血浆浓度变化：基于生理的药代动力学模型在理解其对疗效影响方面的应用
Pharmaceutics. 2023 Oct 13;15(10):2455. doi: 10.3390/pharmaceutics15102455.
7
Informing a Comprehensive Risk Assessment of Infant Drug Exposure From Human Milk: Application of a Physiologically Based Pharmacokinetic Lactation Model for Sotalol.从人乳中告知婴儿药物暴露的综合风险评估：索他洛尔生理基于药代动力学的泌乳模型的应用。
J Clin Pharmacol. 2023 Jun;63 Suppl 1:S106-S116. doi: 10.1002/jcph.2242.
8
Quantitative approaches to drug safety: The 2022 PSP special issue.药物安全性的定量方法：2022年PSP特刊
CPT Pharmacometrics Syst Pharmacol. 2022 May;11(5):529-531. doi: 10.1002/psp4.12804.
预测哺乳期母乳中药物浓度，将预测算法整合到基于生理学的药代动力学模型中。
CPT Pharmacometrics Syst Pharmacol. 2021 Aug;10(8):878-889. doi: 10.1002/psp4.12662. Epub 2021 Jul 2.
4
Physiologically Based Pharmacokinetic Modeling of CFTR Modulation in People with Cystic Fibrosis Transitioning from Mono or Dual Regimens to Triple-Combination Elexacaftor/Tezacaftor/Ivacaftor.囊性纤维化患者从单药或双药治疗方案转换为三联组合疗法依列卡福/替扎卡福/依伐卡福时CFTR调节剂的基于生理的药代动力学建模
Pulm Ther. 2020 Dec;6(2):275-286. doi: 10.1007/s41030-020-00124-7. Epub 2020 Jul 30.
5
Clinical lactation studies and the role of pharmacokinetic modeling and simulation in predicting drug exposures in breastfed infants.临床哺乳研究以及药代动力学建模和模拟在预测母乳喂养婴儿药物暴露中的作用。
J Pharmacokinet Pharmacodyn. 2020 Aug;47(4):295-304. doi: 10.1007/s10928-020-09676-2. Epub 2020 Feb 7.
6
Measured fetal and neonatal exposure to Lumacaftor and Ivacaftor during pregnancy and while breastfeeding.测量妊娠期和哺乳期胎儿和新生儿暴露于 Lumacaftor 和 Ivacaftor 的情况。
J Cyst Fibros. 2018 Nov;17(6):779-782. doi: 10.1016/j.jcf.2018.05.009. Epub 2018 Jun 1.
7
Towards a Best Practice Approach in PBPK Modeling: Case Example of Developing a Unified Efavirenz Model Accounting for Induction of CYPs 3A4 and 2B6.迈向PBPK建模的最佳实践方法：开发一个统一的依非韦伦模型以考虑细胞色素P450 3A4和2B6诱导作用的案例
CPT Pharmacometrics Syst Pharmacol. 2016 Jul;5(7):367-76. doi: 10.1002/psp4.12088. Epub 2016 Jul 20.
8
Breast milk pharmacokinetics of efavirenz and breastfed infants' exposure in genetically defined subgroups of mother-infant pairs: an observational study.依非韦伦的母乳药代动力学及母婴配对基因定义亚组中母乳喂养婴儿的暴露情况：一项观察性研究。
Clin Infect Dis. 2015 Aug 1;61(3):453-63. doi: 10.1093/cid/civ317. Epub 2015 Apr 16.
9
Models and methods for predicting drug transfer into human milk.预测药物向人乳中转移的模型与方法。
Adv Drug Deliv Rev. 2003 Apr 29;55(5):643-52. doi: 10.1016/s0169-409x(03)00032-2.