Groeger Sabine, Zhou Yuxi, Ruf Sabine, Meyle Joerg
Department of Periodontology, Justus-Liebig-University of Giessen, Giessen, Germany.
Department of Orthodontics, Justus-Liebig-University of Giessen, Giessen, Germany.
Front Oral Health. 2022 Apr 5;3:831607. doi: 10.3389/froh.2022.831607. eCollection 2022.
Periodontitis is an oral chronic inflammatory disease and may cause tooth loss in adults. Oral epithelial cells provide a barrier for bacteria and participate in the immune response. () is one of the common inhabitants of the oral cavity and has been identified as a potential etiologic bacterial agent of oral diseases, such as periodontitis and oral carcinomas. has been shown to be of importance in the development of diverse human cancers. In the dental biofilm, it exhibits a structural role as a bridging organism, connecting primary colonizers to the largely anaerobic secondary colonizers. It expresses adhesins and is able to induce host cell responses, including the upregulation of defensins and the release of chemokines and interleukins. Like other microorganisms, its detection is achieved through germline-encoded pattern-recognition receptors (PRRs) and pathogen-associated molecular patterns (PAMPs). By identification of the pathogenic mechanisms of it will be possible to develop effective methods for the diagnosis, prevention, and treatment of diseases in which a infection is involved. This review summarizes the recent progress in research targeting and its impact on oral epithelial cells.
牙周炎是一种口腔慢性炎症性疾病，可能导致成年人牙齿脱落。口腔上皮细胞为细菌提供屏障并参与免疫反应。（某细菌名称未给出）是口腔的常见定植菌之一，已被确定为牙周炎和口腔癌等口腔疾病的潜在病因细菌。（某细菌名称未给出）已被证明在多种人类癌症的发展中具有重要作用。在牙菌斑中，它作为一种桥梁生物发挥结构作用，将早期定植菌与主要为厌氧菌的后期定植菌连接起来。它表达黏附素，并能够诱导宿主细胞反应，包括防御素的上调以及趋化因子和白细胞介素的释放。与其他微生物一样，其检测是通过种系编码的模式识别受体（PRR）和病原体相关分子模式（PAMP）来实现的。通过确定（某细菌名称未给出）的致病机制，将有可能开发出针对涉及（某细菌名称未给出）感染的疾病的有效诊断、预防和治疗方法。本综述总结了针对（某细菌名称未给出）及其对口腔上皮细胞影响的研究最新进展。
