以2-氨基苯并咪唑为结构单元，微波辅助绿色构建咪唑稠合杂化支架。
Microwave-assisted green construction of imidazole-fused hybrid scaffolds using 2-aminobenzimidazoles as building blocks.
作者信息
Kwak Jung Pyo, Quang Dao Pham Duy, Yoon Nam Sik, Cho Chan Sik
机构信息
Department of Applied Chemistry, Kyungpook National University 80 Daehakro, Bukgu Daegu 41566 Republic of Korea
Department of Textile System Engineering, Kyungpook National University 80 Daehakro, Bukgu Daegu 41566 Republic of Korea.
出版信息
RSC Adv. 2021 Jun 17;11(35):21367-21374. doi: 10.1039/d1ra04396j. eCollection 2021 Jun 15.
A class of trinuclear imidazole-fused hybrid scaffolds was constructed by the reaction of 2-(2-bromoaryl)- and 2-(2-bromovinyl)imidazoles with 2-aminobenzimidazoles as building blocks in the presence of a base under microwave irradiation. A nucleophilic aromatic substitution followed by cyclization is proposed as a reaction pathway of this green process.
通过2-(2-溴芳基)-和2-(2-溴乙烯基)咪唑与2-氨基苯并咪唑作为结构单元在碱存在下于微波辐射下反应，构建了一类三核咪唑稠合杂化支架。亲核芳香取代随后环化被认为是该绿色过程的反应途径。
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