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微波辅助在温和碱性条件下的环化反应：6H-苯并[c]色烯-6-酮及其 7,8,9,10-四氢类似物的合成。

Microwave-Assisted Cyclization under Mildly Basic Conditions: Synthesis of 6 H-Benzo[ c]chromen-6-ones and Their 7,8,9,10-Tetrahydro Analogues.

机构信息

Department of Applied Chemistry , Kyungpook National University , 80 Daehakro , Bukgu, Daegu 41566 , Republic of Korea.

Department of Environmental Engineering , Kyungpook National University , 80 Daehakro , Bukgu, Daegu 41566 , Republic of Korea.

出版信息

J Org Chem. 2018 Apr 6;83(7):4140-4146. doi: 10.1021/acs.joc.8b00048. Epub 2018 Mar 26.

DOI:10.1021/acs.joc.8b00048
PMID:29564893
Abstract

Aryl 2-bromobenzoates and aryl 2-bromocyclohex-1-enecarboxylates are cyclized by microwave irradiation in dimethylformamide in the presence of KCO to give the corresponding 6 H-benzo[ c]chromen-6-ones and their 7,8,9,10-tetrahydro analogues, respectively, in 50-72% yields. Aryl 3-bromoacrylates are also converted into 2 H-chromen-2-ones under the employed conditions.

摘要

芳基 2-溴苯甲酸盐和芳基 2-溴环己-1-烯羧酸酯在二甲基甲酰胺中在 KCO 的存在下通过微波辐射环化，分别得到相应的 6H-苯并[c]色烯-6-酮及其 7,8,9,10-四氢类似物，产率为 50-72%。在采用的条件下，芳基 3-溴丙烯酰胺也转化为 2H-色烯-2-酮。

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