Zhang Guo-Min, Zhang Hua, Wang Bei, Wang Ji-Yu
Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences Chengdu 610041 P. R. China
University of Chinese Academy of Sciences Beijing 100049 P. R. China.
RSC Adv. 2021 May 10;11(28):17025-17031. doi: 10.1039/d1ra01922h. eCollection 2021 May 6.
A metal-free catalytic allylation with atom economy and green environment friendly was developed. Allylic alcohols could be directly dehydrated in water by B(CF), without using any base additives. The reaction can afford the corresponding monoallylated product in moderate to high yield and has been performed on a gram-scale, and a quaternary carbon center can be constructed for the active methine compounds of 1,3-diketones or β-ketone esters in this process. The product can be further converted, such as the synthesis of tetra-substituted pyrazole compounds, or 1,4-dienes and functionalized dihydropyrans.
开发了一种具有原子经济性且绿色环保的无金属催化烯丙基化反应。烯丙醇可在水中通过B(CF)直接脱水，无需使用任何碱添加剂。该反应能以中等到高的产率得到相应的单烯丙基化产物，并且已进行了克级规模的反应，在此过程中可为1,3 - 二酮或β - 酮酯的活性次甲基化合物构建季碳中心。产物可进一步转化，例如合成四取代吡唑化合物、1,4 - 二烯和官能化二氢吡喃。
