Li Wu, Werner Thomas
Leibniz Institute for Catalysis at the University of Rostock , Albert-Einstein-Straße 29a, 18059 Rostock, Germany.
Org Lett. 2017 May 19;19(10):2568-2571. doi: 10.1021/acs.orglett.7b00720. Epub 2017 May 11.
The Michael reaction is a widely used reaction for the C-C coupling of electron-poor olefins and C(sp)-H pronucleophiles. Herein we report the Michael reaction between alkenes and aromatic as well as heteroaromatic compounds as aromatic C(sp)-H nucleophiles under mild conditions. The reaction is catalyzed by readily available Lewis acidic B(CF) and proceeds with high regioselectivity for a wide substrate scope.
迈克尔反应是一种广泛用于贫电子烯烃与C(sp)-H亲核前体进行C-C偶联的反应。在此，我们报道了在温和条件下，烯烃与作为芳族C(sp)-H亲核试剂的芳族以及杂芳族化合物之间的迈克尔反应。该反应由易于获得的路易斯酸性B(CF)催化，并且对于广泛的底物范围具有高区域选择性。
