膀胱癌中血型抗原与癌胚抗原的研究
Investigation of blood group antigens and carcinoembryonic antigen in urinary bladder carcinoma.
作者信息
Fujioka T, Ohhori T, Lovrekovich L, deKernion J B
出版信息
Urol Int. 1986;41(6):397-402. doi: 10.1159/000281242.
Blood group antigens and carcinoembryonic antigen (CEA) were sought in the tissues of 37 bladder tumor cases using enzyme antibody method. A correlation (p less than 0.01) was found between the extinction of ABO (H) and progressive malignant states of the tumor or invasion stage. Significant correlation (p less than 0.05) was observed between the presence of CEA and the invasion stage. The state of the T antigen, however, did not reflect the malignancy grade or invasion stage. The states of ABO (H) and CEA significantly reflected (p less than 0.05) the prognosis, as did the malignancy grade and invasion stage, while the state of the T antigen did not correlate with the prognosis. Although there was a correlation (p less than 0.01) between the extinction of ABO (H) blood group antigens and the presence of CEA, the state of T antigen did not significantly correlate with ABO (H) antigen or CEA. From what has been mentioned, the search for intratissue ABO (H) antigens and CEA is important and will provide a useful auxiliary means in diagnosing biopsy specimens.
采用酶抗体法在37例膀胱肿瘤组织中检测血型抗原和癌胚抗原（CEA）。发现ABO（H）抗原的消光与肿瘤的进展恶性状态或浸润阶段之间存在相关性（p<0.01）。观察到CEA的存在与浸润阶段之间存在显著相关性（p<0.05）。然而，T抗原的状态并未反映恶性程度或浸润阶段。ABO（H）和CEA的状态显著反映了预后（p<0.05），恶性程度和浸润阶段也是如此，而T抗原的状态与预后无关。虽然ABO（H）血型抗原的消光与CEA的存在之间存在相关性（p<0.01），但T抗原的状态与ABO（H）抗原或CEA无显著相关性。综上所述，检测组织内ABO（H）抗原和CEA很重要，将为诊断活检标本提供有用的辅助手段。
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