Wiley E L, Mendelsohn G, Droller M J, Eggleston J C
J Urol. 1982 Aug;128(2):276-80. doi: 10.1016/s0022-5347(17)52885-2.
Immunoperoxidase localization of A and B blood group substances and carcinoembryonic antigen in papillary transitional cell carcinoma of the bladder demonstrated blood group substances in 22 of 48 carcinomas and trace amounts of carcinoembryonic antigen in 26. All 22 cases of transitional cell carcinoma positive for blood group substances were stage O (noninvasive) and 21 were grade I or II (well differentiated). Of 26 tumors negative for blood group substances 14 were grade III (poorly differentiated). Of 17 patients who had tumors positive for blood group substances at any time no positive tumor was followed by invasive carcinoma. In contrast, of 17 patients who had tumors negative for blood group substances 15 either had invasive carcinoma at the time of diagnosis or later. Carcinoembryonic antigen positivity did not correlate with pathologic stage, histologic grade or clinical course.
免疫过氧化物酶法对膀胱乳头状移行细胞癌中A和B血型物质及癌胚抗原的定位显示，48例癌中有22例存在血型物质，26例有微量癌胚抗原。血型物质阳性的22例移行细胞癌均为O期（非浸润性），21例为I级或II级（高分化）。26例血型物质阴性的肿瘤中，14例为III级（低分化）。17例曾有血型物质阳性肿瘤的患者中，无阳性肿瘤发展为浸润性癌。相反，17例血型物质阴性肿瘤的患者中，15例在诊断时或之后出现浸润性癌。癌胚抗原阳性与病理分期、组织学分级或临床病程无关。
