氟比洛芬酯联合“鸡尾酒”疗法对全膝关节置换术后患者阿片类药物用量的影响
Effect of flurbiprofen axetil combined with "Cocktail" therapy on opioid dosage in patients after total knee arthroplasty.
作者信息
Wang Lu, Wu Li-Xin, Han Zhe, Ma Wen-Hai, Geng Zhi-Hui
机构信息
Lu Wang, Department of Pharmacy, Baoding No.1 Central Hospital, Baoding 071000, Hebei, China.
Li-xin Wu, Department of Pharmacy, Baoding No.1 Central Hospital, Baoding 071000, Hebei, China.
出版信息
Pak J Med Sci. 2022 Mar-Apr;38(3Part-I):724-729. doi: 10.12669/pjms.38.3.4735.
OBJECTIVES
To investigate the effect of flurbiprofen axetil combined with "cocktail" therapy on opioid dosage in patients after total knee arthroplasty (TKA).
METHODS
The clinical data of 200 patients who underwent TKA in Baoding No.1 Central Hospital hospital from March 2019 to March 2021 were collected for retrospective analysis. All 200 patients were divided into two groups according to their intraoperative anesthesia methods: the control group (100 cases) and the experimental group (100 cases). Patients in the control group were treated with "cocktail" therapy intraoperatively, while those in the experimental group were treated with flurbiprofen axetil combined with "cocktail" therapy intraoperatively. The hip pain scores in resting state and motion state were compared between the two groups at different postoperative time points, and postoperative pain relief, adverse reactions, and patient satisfaction with analgesia were statistically analyzed to evaluate the postoperative quality of life of the patients.
RESULTS
A statistically significant difference was observed in the intergroup and temporal effects of pain scores in resting state and motion state between the two groups (p<0.05). By comparison at each time point, the pain scores in the experimental group were significantly lower than those in the control group at the time point T1-T6 in resting and motion states, with a statistically significant difference (p<0.05). The frequency and dosage of remedial medication per capita in the experimental group were significantly lower than those in the control group, with a statistical significance (p<0.05). There was no significant difference in the scores of life quality items between the two groups preoperatively (p>0.05), while the scores of each item in the experimental group were significantly higher than those in the control group postoperatively (p<0.05). The satisfaction degree of the experimental group was significantly higher than that of the control group, showing a statistically significant difference (p<0.05).
CONCLUSIONS
Flurbiprofen axetil combined with "cocktail" therapy is a safe treatment regimen that can improve the quality of life and safety of patients. With such a regimen, postoperative pain of patients undergoing TKA can be effectively relieved, and the use of opioids can be reduced.
目的
探讨氟比洛芬酯联合“鸡尾酒”疗法对全膝关节置换术（TKA）患者阿片类药物用量的影响。
方法
收集2019年3月至2021年3月在保定市第一中心医院行TKA的200例患者的临床资料进行回顾性分析。将200例患者根据术中麻醉方式分为两组：对照组（100例）和试验组（100例）。对照组术中采用“鸡尾酒”疗法，试验组术中采用氟比洛芬酯联合“鸡尾酒”疗法。比较两组在术后不同时间点静息状态和运动状态下的髋部疼痛评分，并对术后疼痛缓解情况、不良反应及患者对镇痛的满意度进行统计学分析，以评估患者术后生活质量。
结果
两组静息状态和运动状态下疼痛评分的组间效应和时间效应差异有统计学意义（p<0.05）。各时间点比较，试验组在静息和运动状态下T1-T6时间点的疼痛评分均显著低于对照组，差异有统计学意义（p<0.05）。试验组人均补救用药频率和用量均显著低于对照组，差异有统计学意义（p<0.05）。两组术前生活质量项目评分差异无统计学意义（p>0.05），而试验组术后各项目评分均显著高于对照组（p<0.05）。试验组满意度显著高于对照组，差异有统计学意义（p<0.05）。
结论
氟比洛芬酯联合“鸡尾酒”疗法是一种安全的治疗方案，可提高患者生活质量和安全性。采用该方案可有效缓解TKA患者术后疼痛，减少阿片类药物的使用。
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