Li Xiaoying, Jiang Zinan
Xiaoying Li, MD. Department of Emergency, The Third Xiangya Hospital, Central South University; No. 138, Tongzipo Road, Changsha 410013, Hunan Province, P.R. China.
Zinan Jiang, MD. Department of Emergency, The Third Xiangya Hospital, Central South University; No. 138, Tongzipo Road, Changsha 410013, Hunan Province, P.R. China.
Pak J Med Sci. 2022 Mar-Apr;38(3Part-I):600-604. doi: 10.12669/pjms.38.3.5329.
To assess the association of bronchoalveolar lavage fluid (BALF) α-SMA and ß-catenin levels and the severity of pneumonia.
The records of patients with severe pneumonia treated in our hospital from June 2019 to June 2020 were selected. The clinical outcome was observed within 10 days. For the purpose of analysis, patients were divided into two groups according to the outcome, 47 cases in the improvement group and 39 cases in the deterioration group. The intubation time, mechanical ventilation time and APACHE II score 10 days after admission were compared between the two groups; We assessed pulmonary infections using the clinical pulmonary infection score(CPIS). The levels of α-SMA and ß-catenin in bronchoalveolar lavage fluid at different time points were compared and analyzed, to analyze the association between the levels and the CPIS.
The APACHE II score in the improvement group were lower than those in the deterioration group (P<0.05). The expressions of α-SMA and ß-catenin in the BALF of patients in the improvement group were significantly lower than those of patients in the deterioration group on day 1, 3, and 7 (P<0.05); and the expressions of α-SMA and ß-catenin in the BALF of patients in the improvement group decreased with time, while those of patients in the deterioration group increased gradually with time(P<0.05). The expressions of α-SMA and ß-catenin in patients with CPIS>6 was significantly higher than those in patients with CPI≤6(P<0.05). Pearson correlation analysis showed that the levels of α-SMA and ß-catenin in BALF were positively correlated with the CPIS.
The levels of α-SMA and ß-catenin in BALF are closely associated with the clinical condition of patients with severe pneumonia; the levels are positively associated with the severity of the disease and they increase with symptomatic worsening.
评估支气管肺泡灌洗液（BALF）中α-平滑肌肌动蛋白（α-SMA）和β-连环蛋白水平与肺炎严重程度的相关性。
选取2019年6月至2020年6月在我院接受治疗的重症肺炎患者的病历。观察10天内的临床结局。为便于分析，根据结局将患者分为两组，改善组47例，恶化组39例。比较两组患者入院10天后的插管时间、机械通气时间和急性生理与慢性健康状况评分系统II（APACHE II）评分；采用临床肺部感染评分（CPIS）评估肺部感染情况。比较并分析不同时间点支气管肺泡灌洗液中α-SMA和β-连环蛋白的水平，以分析这些水平与CPIS之间的相关性。
改善组的APACHE II评分低于恶化组（P<0.05）。改善组患者第1、3和7天BALF中α-SMA和β-连环蛋白的表达明显低于恶化组患者（P<0.05）；改善组患者BALF中α-SMA和β-连环蛋白的表达随时间下降，而恶化组患者的表达随时间逐渐升高（P<0.05）。CPIS>6的患者中α-SMA和β-连环蛋白的表达明显高于CPIS≤6的患者（P<0.05）。Pearson相关性分析显示，BALF中α-SMA和β-连环蛋白水平与CPIS呈正相关。
BALF中α-SMA和β-连环蛋白水平与重症肺炎患者的临床状况密切相关；这些水平与疾病严重程度呈正相关，且随症状恶化而升高。
