Alareqi Amal A, Alshoabi Sultan Abdulwadoud, Qurashi Abdulaziz A, Hamid Abdullgabbar M
Amal A. Alareqi, Department of Radiology, University of Science and Technology Hospital (USTH), Sana'a, Republic of Yemen. Radiology Department, 21 September University of Medical and Applied Sciences, Sana'a, Republic of Yemen.
Sultan Abdulwadoud Alshoabi, Department of Diagnostic Radiology Technology, College of Applied Medical Sciences, Taibah University, Almadinah Almunawwarah, Kingdom of Saudi Arabia.
Pak J Med Sci. 2022 Mar-Apr;38(3Part-I):674-681. doi: 10.12669/pjms.38.3.4699.
Diabetes mellitus (DM) is a common endocrine disease with serious effects on multiple organs including the kidneys. This study aimed to investigate the subtle effects of type 2 DM (T2DM) on the kidneys.
This was a prospective case-control study conducted in the Radiology Department of University of Science and Technology Hospital (USTH) campus, Sana'a, Republic of Yemen, from 1 January 2020 to 31 November 2020. The renal length (RL), renal width (RW), resistive index (RI), and pulsatility index (PI) were prospectively measured in patients with T2DM and healthy controls. The results were compared using the independent samples t-test. Comparisons were likewise performed between patients with controlled DM and patients with uncontrolled DM.
A total of hundred individuals, 50 diabetic patients and 50 controls, were enrolled in this study. Their mean age was 54 ± 7.88 years (range: 40-75 years). The RL, RI, and PI of both kidneys were significantly higher in T2DM than in the control group. Moreover, the RL, RI, PI and creatinine were slightly higher in patients with uncontrolled than in those with controlled DM.
T2DM has significant accentuating effects on the RL, RI and PI associated with low effective renal plasma flow, even before acute kidney injury or chronic kidney disease diagnosis, which may be attenuated by careful regulation of DM. Ultrasound Doppler is a highly valuable imaging modality for evaluating the subtle effects of T2DM on kidney dimensions and blood flow. The RI can be implemented as a tool for the early diagnosis of kidney disease and contribute to slowing the disease progression and preventing renal failure.
糖尿病（DM）是一种常见的内分泌疾病，对包括肾脏在内的多个器官有严重影响。本研究旨在探讨2型糖尿病（T2DM）对肾脏的细微影响。
这是一项前瞻性病例对照研究，于2020年1月1日至2020年11月31日在也门共和国萨那科技大学医院（USTH）校区放射科进行。前瞻性测量T2DM患者和健康对照者的肾长（RL）、肾宽（RW）、阻力指数（RI）和搏动指数（PI）。结果采用独立样本t检验进行比较。同样对血糖控制良好的糖尿病患者和血糖控制不佳的糖尿病患者进行了比较。
本研究共纳入100人，其中糖尿病患者50例，对照组50例。他们的平均年龄为54±7.88岁（范围：40 - 75岁）。T2DM患者双肾的RL、RI和PI均显著高于对照组。此外，血糖控制不佳的患者的RL、RI、PI和肌酐略高于血糖控制良好的患者。
即使在急性肾损伤或慢性肾病诊断之前，T2DM对与低有效肾血浆流量相关的RL、RI和PI也有显著的加重作用，通过仔细控制糖尿病可能会减轻这种作用。超声多普勒是评估T2DM对肾脏大小和血流细微影响的一种非常有价值的成像方式。RI可作为肾病早期诊断的工具，有助于减缓疾病进展并预防肾衰竭。
