He Panqi, Liao Limin
Department of Urology, School of Rehabilitation, China Rehabilitation Research Center, Beijing Bo'ai Hospital, Capital Medical University, Beijing, China.
China Rehabilitation Science Institute, Beijing, China.
Front Physiol. 2024 Dec 9;15:1501161. doi: 10.3389/fphys.2024.1501161. eCollection 2024.
Glomerular filtration rate (GFR) measured by dynamic renal scintigraphy (Gates method) is used in this study as the standard to investigate the applicability of two creatinine (Cr)-based GFR estimation equations in Chinese patients of different genders, age groups, and GFR stages diagnosed with neurogenic bladder (NB).
GFR values were measured using Tc-DTPA renal dynamic imaging, the new serum creatinine (Cr)-based chronic kidney disease epidemiology collaborative group (CKD-EPI) equation, and the equation for the estimated GFR of CKD patients in China, which were designated as sGFR, EPI-GFR, and cGFR, respectively. Pearson's correlation and linear regression were used to compare the differences, absolute differences, precision, and accuracies of the results of the two equations with sGFR to determine the formula offering better performance for the assessment of patients with NB.
Measurements from a total of 99 patients with NB were used in the final analysis. Both cGFR and EPI-GFR were moderately correlated with sGFR in both men and women. The overall staging accuracies of EPI-GFR and sGFR were significantly higher than that of cGFR. Among the patients staged, only those with GFRs in the range of 60-89 mL/min/1.73 m had moderate correlations between cGFR, EPI-GFR, and sGFR, while the remaining patients had low correlations.
Researchers found that the equation developed for Chinese CKD patients performed well for patients with NB aged 20-25 years, while the race-neutral CKD-EPI equation performed better in NB patients aged 26-35 years.
本研究采用动态肾闪烁显像法（盖茨法）测量的肾小球滤过率（GFR）作为标准，以研究两种基于肌酐（Cr）的GFR估算方程在中国不同性别、年龄组以及诊断为神经源性膀胱（NB）的不同GFR阶段患者中的适用性。
采用Tc-DTPA肾动态显像测量GFR值，使用新的基于血清肌酐（Cr）的慢性肾脏病流行病学协作组（CKD-EPI）方程以及中国CKD患者估算GFR的方程，分别将其指定为sGFR、EPI-GFR和cGFR。采用Pearson相关性分析和线性回归比较这两个方程与sGFR结果的差异、绝对差异、精密度和准确性，以确定在评估NB患者时表现更好的公式。
最终分析共纳入99例NB患者的测量数据。男性和女性患者中，cGFR和EPI-GFR与sGFR均呈中度相关。EPI-GFR和sGFR的总体分期准确性显著高于cGFR。在分期的患者中，仅GFR在60-89 mL/min/1.73 m范围内者cGFR、EPI-GFR和sGFR之间具有中度相关性，其余患者相关性较低。
研究人员发现，为中国CKD患者开发的方程在20-25岁的NB患者中表现良好，而种族中性的CKD-EPI方程在26-35岁的NB患者中表现更佳。
