El-Khateeb Ayman Y, Hamed Sahar E, Elattar Khaled M
Agricultural Chemistry Department, Faculty of Agriculture, Mansoura University El-Gomhoria Street Mansoura 35516 Egypt
Chemistry Department, Faculty of Agriculture, Damietta University Damietta 22052 Egypt
RSC Adv. 2022 Apr 19;12(19):11808-11842. doi: 10.1039/d2ra00927g. eCollection 2022 Apr 13.
Heterocyclic compounds incorporated with a pyranopyrimidine skeleton have received substantial consideration owing to their privileged, and intelligible biodiversity. Accordingly, this review highlights the multicomponent synthetic routes adopted to prepare heterocyclic compounds incorporated with the pyrano[2,3-]pyrimidine skeleton in the preceding two years. The different sections comprise the synthesis of bicyclic, tricyclic, polycyclic, and spirocyclic systems along with the estimation of the probable mechanistic routes for the reaction pathways. Commonly, the pyran ring closure was the major idea of most studies, and the mechanistic pathways of these reactions involved Knoevenagel condensation, Michael addition, and intramolecular cyclocondensation. Besides, the significant biological potency of the compounds recently synthesized from multicomponent reactions is deliberated.
含有吡喃并嘧啶骨架的杂环化合物因其独特且清晰的生物多样性而受到广泛关注。因此，本综述重点介绍了过去两年中用于制备含有吡喃并[2,3 -]嘧啶骨架的杂环化合物的多组分合成路线。不同部分包括双环、三环、多环和螺环体系的合成以及对反应途径可能的机理路线的评估。通常，吡喃环的闭合是大多数研究的主要思路，这些反应的机理途径涉及克诺文纳格尔缩合、迈克尔加成和分子内环化缩合。此外，还讨论了最近通过多组分反应合成的化合物的显著生物活性。
