Monier Mohamed, Abdel-Latif Doaa, El-Mekabaty Ahmed, Mert Başak D, Elattar Khaled M
Chemistry Department, Faculty of Science, Mansoura University, El-Gomhoria Street, Mansoura 35516, Egypt.
Department of Energy Systems Engineering, Adana Alparslan Turkes Science and Technology University, Adana 01250, Turkey.
Curr Org Synth. 2019;16(6):812-854. doi: 10.2174/1570179416666190704113647.
The aim of this work is to discuss the chemistry of pyrido[3,4-d]pyrimidines as one of the most important heterocyclic compounds with remarkable synthetic, biological and medical applications. In this overview, the chemistry of heterocyclic compounds incorporated the pyrido[3,4-d]pyrimidine scaffold as demonstrated by chemical reactions and different preparation processes. The anticipated compounds were synthesized from pyridine or pyrimidine compounds and a description of the reactivity of substituents attached to ring carbon and nitrogen atoms is discussed. On the other hand, the synthesis and reactions of fused heterocycles incorporated pyrido[3,4-d]pyrimidine scaffold is described. The diamine analogs included pyrido[3,4-d]pyrimidine core were reported as tyrosine kinase inhibitors. The chemical reactions of certain unexpected and chemically substantial compounds have been discussed.
这项工作的目的是讨论吡啶并[3,4-d]嘧啶的化学性质，它是最重要的杂环化合物之一，具有显著的合成、生物学和医学应用。在本综述中，通过化学反应和不同的制备过程展示了含有吡啶并[3,4-d]嘧啶骨架的杂环化合物的化学性质。预期的化合物由吡啶或嘧啶化合物合成，并讨论了连接在环碳和氮原子上的取代基的反应性。另一方面，描述了含有吡啶并[3,4-d]嘧啶骨架的稠合杂环的合成和反应。报道了含吡啶并[3,4-d]嘧啶核心的二胺类似物作为酪氨酸激酶抑制剂。还讨论了某些意外的和具有重要化学意义的化合物的化学反应。
