Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.
Org Biomol Chem. 2022 May 18;20(19):3897-3901. doi: 10.1039/d2ob00547f.
A nucleophilic aromatic substitution (SAr) reaction that allowed transition-metal-free C-P bond construction C-N bond cleavage was developed. The coupling between aryltrimethylammonium salts and secondary phosphines from the reduction of diarylphosphine oxides led to the formation of diverse triarylphosphines with various functional groups. This one-pot process was not only a pertinent SAr precedent but also a favorable transition-metal-free alternative for C-P coupling.
开发了一种亲核芳香取代（SAr）反应，允许在无过渡金属的情况下构建 C-P 键并断裂 C-N 键。芳基三甲基铵盐与二芳基氧化膦还原得到的仲膦之间的偶联反应导致各种具有不同官能团的三芳基膦的形成。该一锅法不仅是一个恰当的 SAr 前例，也是一种有利的无过渡金属替代方案，用于 C-P 偶联。
