二芳基砜基三氟甲磺酸酯的制备及其在钯催化交叉偶联反应中的应用。
The Preparation of Diaryl Sulfoxinium Triflates and Their Application in Palladium-Catalyzed Cross-Coupling Reactions.
机构信息
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
University of Jyvaskyla, Department of Chemistry, FI-40014, Jyväskylä, Finland.
出版信息
Chem Asian J. 2022 Oct 4;17(19):e202200828. doi: 10.1002/asia.202200828. Epub 2022 Aug 29.
Treatment of N-methyl-S,S-diaryl sulfoximines with methyl trifluoromethanesulfonate provides bench-stable sulfoxinium salts in excellent yields. Applying them in Sonogashira-, Heck- and Suzuki-type cross-coupling reactions leads to the corresponding products by sequential C-S bond cleavage and C-C bond formation. Electronic factors induced by substituents on the S-aryl groups govern the coupling efficiency.
用三氟甲磺酸甲酯处理 N-甲基-S,S-二芳基磺亚胺可以得到在实验台上稳定的磺亚铵盐，产率优异。将它们应用于 Sonogashira、Heck 和 Suzuki 型交叉偶联反应中，通过顺序的 C-S 键断裂和 C-C 键形成，可以得到相应的产物。S-芳基取代基诱导的电子因素控制着偶联效率。
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