Akiel Maaged A, Mohamud Mohamud S, Masuadi Emad M, Alamri Hassan S
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Kingdom of Saudi Arabia.
King Abdullah International Medical Research Center (KAIMRC), Riyadh, Kingdom of Saudi Arabia.
Mol Genet Genomic Med. 2022 Jul;10(7):e1960. doi: 10.1002/mgg3.1960. Epub 2022 Apr 28.
Noninvasive prenatal testing (NIPT) is a screening tool for chromosomal aneuploidies. Prior knowledge of NIPT is an inherent factor in the decision-making process. We assessed the knowledge and attitude of pregnant women related to prenatal testing with a particular focus on NIPT.
A prospective cross-sectional study, using a culturally validated questionnaire, was conducted with 342 pregnant women of whom 74.9% consented for prenatal screening. Mean age and gestational weeks ± standard deviation was 31 ± 5 and 26 ± 11, respectively.
A positive/very positive attitude was observed to ultrasound, followed by FCT, NIPT, and lastly to CVS. More than half of the participants (56.1%) had no previous knowledge of NIPT. A reaching significance association was detected between education and knowledge of NIPT. Significant association was detected between risk for aneuploidy and knowledge of NIPT. The majority (74%) indicated their willingness to perform the test. The effect and value of society on the pregnant women to make a decision regarding NIPT was negligible.
The pregnant women in the current study displayed a lack of knowledge and awareness regarding prenatal screening, particularly the NIPT. We recommend that pregnant women receive adequate counseling regarding prenatal screening to increase their awareness and knowledge of prenatal testing, including NIPT.
无创产前检测(NIPT)是一种用于筛查染色体非整倍体的工具。对NIPT的先验知识是决策过程中的一个内在因素。我们评估了孕妇对产前检测的知识和态度,特别关注NIPT。
采用经过文化验证的问卷进行前瞻性横断面研究,对342名孕妇进行了调查,其中74.9%的孕妇同意进行产前筛查。平均年龄和孕周±标准差分别为31±5岁和26±11周。
对超声检查的态度为积极/非常积极,其次是FCT、NIPT,最后是绒毛取样(CVS)。超过一半的参与者(56.1%)之前对NIPT一无所知。在教育程度与NIPT知识之间检测到显著关联。在非整倍体风险与NIPT知识之间检测到显著关联。大多数人(74%)表示愿意进行该项检测。社会因素对孕妇就NIPT做出决策的影响和价值可忽略不计。
本研究中的孕妇对产前筛查,尤其是NIPT,缺乏知识和认识。我们建议孕妇接受关于产前筛查的充分咨询,以提高她们对包括NIPT在内的产前检测的认识和知识。