Ekman G, Granström L, Ulmsten U
Acta Obstet Gynecol Scand. 1986;65(8):857-9. doi: 10.3109/00016348609157038.
Thirty-eight term pregnant women with a moderately unfavorable cervix (cervical score 4-5 p.) were randomly given intravenous oxytocin (Group A) or 3 mg PGE2 as a vaginal suppository (Group B) for labor induction. Eight out of 19 in Group A and 17 out of 19 in Group B gave birth vaginally within 24 h. The remaining 11 women in Group A had still an unfavorable cervix after 24 h. They were then given 3 mg PGE2 as a vaginal suppository and all but one had given birth vaginally without complications within 24 h. In Group B only 2 were still undelivered after 24 h. Both had a favorable cervix and were delivered vaginally within 12 h after intravenous infusion of oxytocin. The number of instrumental deliveries in Group A was one cesarean section and two vacuum extractions and in Group B three vacuum extractions. One woman in Group B reported nausea and vomiting and in one had strong uterine contractions in the second stage of labor. Otherwise no side effects were registered. All babies were born in good condition with Apgar scores greater than or equal to 7. In conclusion, vaginal application of 3 mg PGE2 as a suppository seems to be more effective than intravenous infusion of oxytocin for labor induction in women with half-ripened cervices, i.e. cervical scores of 4-5 p.
38名宫颈条件中度不利（宫颈评分4 - 5分）的足月孕妇被随机分为两组，A组静脉滴注缩宫素，B组阴道栓剂给予3mg前列腺素E2用于引产。A组19名中有8名、B组19名中有17名在24小时内阴道分娩。A组其余11名妇女在24小时后宫颈条件仍不利，随后她们也被给予3mg前列腺素E2阴道栓剂，除1名外其余均在24小时内无并发症阴道分娩。B组24小时后只有2名未分娩，她们宫颈条件良好，在静脉滴注缩宫素后12小时内阴道分娩。A组器械助产为1例剖宫产和2例真空吸引，B组为3例真空吸引。B组1名妇女报告恶心呕吐，1名在第二产程出现强烈子宫收缩。除此之外未记录到其他副作用。所有婴儿出生状况良好，阿氏评分大于或等于7分。总之，对于宫颈成熟度为一半（即宫颈评分为4 - 5分）的妇女，阴道栓剂应用3mg前列腺素E2引产似乎比静脉滴注缩宫素更有效。
