School of Health Sciences, Swinburne University of Technology, Hawthorn, Victoria, Australia.
Goulburn Valley Health, Shepparton, Victoria, Australia.
PLoS One. 2022 Apr 28;17(4):e0267593. doi: 10.1371/journal.pone.0267593. eCollection 2022.
Polypharmacy, defined as the concurrent use of multiple medications, is a growing concern globally. This study aimed to identify the significant factors that predict the perceived burden of medication and health-related quality of life.
Adults, aged 18 years and above who have used at least two regular medicines, were invited to complete the study questionnaires between June and October 2019. Multiple linear regression analysis was conducted to identify significant predictors for perceived burden of medication and health-related quality of life.
A total of 119 participants completed this study. The average age of the participants was 63 years (SD±16 years). Factors significantly predicting perceived burden of medication were participants' current health condition (p = 0.001), overall burden of treatment (p<0.001) and being hypertensive (p = 0.037). Similarly, participants' current health condition (p<0.001) and overall burden of treatment (p = 0.086) were significant predictors for perceived health-related quality of life.
This study revealed that hypertensive participants in poor health tended to experience higher perceived burden of medication, which in turn was found to be correlated with lower perceived health-related quality of life.
多种药物疗法（同时使用多种药物）是一个全球性的问题，且日益受到关注。本研究旨在确定可预测药物治疗负担和健康相关生活质量的重要因素。
本研究于 2019 年 6 月至 10 月期间，邀请年龄在 18 岁及以上、至少使用两种常规药物的成年人填写研究问卷。采用多元线性回归分析确定药物治疗负担和健康相关生活质量的显著预测因素。
共 119 名参与者完成了这项研究。参与者的平均年龄为 63 岁（标准差±16 岁）。显著预测药物治疗负担的因素包括参与者当前的健康状况（p = 0.001）、总体治疗负担（p<0.001）和高血压（p = 0.037）。同样，参与者当前的健康状况（p<0.001）和总体治疗负担（p = 0.086）也是感知健康相关生活质量的显著预测因素。
本研究表明，健康状况不佳的高血压参与者往往会经历更高的药物治疗负担，而这种负担又与感知健康相关生活质量降低有关。
