Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 Jan;9(1):50-59. doi: 10.1016/j.bpsc.2022.04.001. Epub 2022 Apr 26.
Research has found overlapping associations in adults of resting-state functional connectivity (RSFC) to both internalizing disorders (e.g., depression, anxiety) and a history of traumatic events. The present study aimed to extend this previous research to a younger sample by examining RSFC associations with both internalizing symptoms and adverse childhood experiences (ACEs) in middle childhood.
We used generalized linear mixed models to examine associations between a priori within- and between-network RSFC with child-reported internalizing symptoms and ACEs using the Adolescent Brain Cognitive Development dataset (N = 10,168, mean age = 9.95 years, SD = 0.627).
We found that internalizing symptoms and ACEs were associated with both multiple overlapping and unique RSFC network patterns. Both ACEs and internalizing symptoms were associated with a reduced anticorrelation between the default mode network and the dorsal attention network. However, internalizing symptoms were uniquely associated with lower within-network default mode network connectivity, while ACEs were uniquely associated with both lower between-network connectivity of the auditory network and cingulo-opercular network, and higher within-network frontoparietal network connectivity.
The present study points to overlap in the RSFC associations with internalizing symptoms and ACEs, as well as important areas of specificity in RSFC associations. Many of the RSFC associations found have been previously implicated in attentional control functions, including modulation of attention to sensory stimuli. This may have critical importance in understanding internalizing symptoms and outcomes of ACEs.
研究发现，静息态功能连接（RSFC）与内化障碍（如抑郁、焦虑）和创伤后经历史在成年人中存在重叠关联。本研究旨在通过检查 RSFC 与儿童中期内化症状和不良童年经历（ACEs）的关联，将这一先前的研究扩展到更年轻的样本中。
我们使用广义线性混合模型，使用青少年大脑认知发展数据集（N=10168，平均年龄=9.95 岁，SD=0.627），检查了儿童报告的内化症状和 ACEs 与预先设定的内在和网络间 RSFC 之间的关联。
我们发现，内化症状和 ACEs 与多个重叠和独特的 RSFC 网络模式相关。ACEs 和内化症状均与默认模式网络和背侧注意网络之间的去关联减少相关。然而，内化症状与默认模式网络内在连接性降低有关，而 ACEs 与听觉网络和扣带前扣带回网络之间的网络间连接性降低以及额顶网络内在连接性升高有关。
本研究表明，RSFC 与内化症状和 ACEs 之间存在重叠关联，并且与 RSFC 关联存在重要的特异性。许多发现的 RSFC 关联先前都与注意力控制功能有关，包括对感觉刺激的注意力调节。这对于理解内化症状和 ACEs 的结果可能具有重要意义。
