PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway; Department of Psychology, Yale University, New Haven, United States.
PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway; Division of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway.
Dev Cogn Neurosci. 2024 Dec;70:101476. doi: 10.1016/j.dcn.2024.101476. Epub 2024 Nov 12.
Parental mental health is associated with children's emotion regulation (ER) and risk for psychopathology. The relationship between parental psychopathology and children's functional ER networks and whether connectivity patterns mediate the relationship between parent and youth psychopathology remains unexplored. Using resting-state functional magnetic resonance imaging data from the Adolescent Brain Cognitive Development Study (N = 4202, mean age = 10.0) and a multilevel approach, we analyzed the relationship between self-reported parental psychopathology and their offsprings' connectivity of four ER networks, as well as associations with self-reported youth psychopathology at a 3-year follow-up. Parental internalizing and total problems were associated with 1) higher connectivity between a subcortical-cortical integrative and ventrolateral prefrontal cortical (PFC) network, 2) lower connectivity between dorsolateral and ventrolateral PFC networks involved in cognitive aspects of ER, and 3) lower connectivity within a subcortical ER network (β = -0.05-0.04). Parental externalizing and total problems were associated with lower connectivity within the integrative network (β = -0.05; β = -0.04). Mediation analyses yielded direct effects of parental to youth psychopathology, but no mediation effect of ER network connectivity. Overall, our results show that ER network connectivity in youth is related to parental psychopathology, yet do not explain intergenerational transmission of psychopathology.
父母的心理健康与孩子的情绪调节（ER）和心理病理学风险有关。父母的心理病理学与孩子的功能性 ER 网络之间的关系，以及连接模式是否在父母和青少年心理病理学之间的关系中起中介作用，这仍然是未知的。我们使用来自青少年大脑认知发展研究（N = 4202，平均年龄 = 10.0）的静息态功能磁共振成像数据和多层次方法，分析了自我报告的父母心理病理学与其后代四个 ER 网络的连接之间的关系，以及与 3 年后自我报告的青少年心理病理学的关联。父母的内在和总体问题与 1）皮质下-皮质综合与腹外侧前额叶皮层（PFC）网络之间的更高连接，2）参与 ER 认知方面的背外侧和腹外侧 PFC 网络之间的更低连接，以及 3）皮质下 ER 网络内的更低连接有关（β= -0.05-0.04）。父母的外在和总体问题与综合网络内的较低连接有关（β= -0.05；β= -0.04）。中介分析得出了父母到青少年心理病理学的直接影响，但 ER 网络连接没有中介作用。总体而言，我们的结果表明，青少年的 ER 网络连接与父母的心理病理学有关，但不能解释心理病理学的代际传递。
