Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada; Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
Manitoba Centre for Health Policy, University of Manitoba, Winnipeg, Manitoba, Canada.
Can J Diabetes. 2022 Jun;46(4):388-391.e3. doi: 10.1016/j.jcjd.2021.12.003. Epub 2021 Dec 23.
Our aim in this study was to determine the best administrative data case definition for pregestational diabetes exposure.
We compared the performance of case definitions for pregestational diabetes exposure within the administrative health data housed in the Manitoba Population Health Research Repository at the Manitoba Centre for Health Policy with an identified population of women in whom the diagnosis of pregestational diabetes was known from the clinical database of the Manitoba Diabetes Education Resource for Children and Adolescents (DER-CA) (August 12, 1989 through January 28, 2015). The DER-CA database contains maternal diabetes status during pregnancy and also includes women diagnosed with type 2 diabetes in childhood whose pregnancies were thus all complicated by pregestational diabetes exposure. Linkage of mother-child dyads is possible within the Repository. Diagnosis codes from the International Classification of Diseases---ninth or tenth revision and physician tariff codes were used to identify diabetes in the biologic mothers of children with type 2 diabetes identified from the DER-CA database. The timing of the diagnosis of diabetes in the mother with respect to the gestational age of the pregnancy was determined.
The best administrative definition of pregestational diabetes exposure was any incident code for diabetes in the mother before the pregnancy of the index child or within the first 25 weeks of pregnancy (sensitivity: 84.77%; positive predictive value: 92%).
The definition cited can be used to define pregestational diabetes exposure in studies utilizing administrative data.
本研究旨在确定适用于妊娠前糖尿病暴露的最佳行政数据病例定义。
我们比较了在马尼托巴省人口健康研究资源库的行政健康数据中妊娠前糖尿病暴露病例定义的性能，该数据来自马尼托巴省儿童和青少年糖尿病教育资源（DER-CA）的临床数据库中已知的妊娠前糖尿病诊断的女性人群（1989 年 8 月 12 日至 2015 年 1 月 28 日）。DER-CA 数据库包含妊娠期间的母体糖尿病状态，还包括在儿童时期被诊断为 2 型糖尿病的女性，其妊娠因此均伴有妊娠前糖尿病暴露。在资源库中可以对母婴对子进行链接。使用国际疾病分类第 9 或第 10 版的诊断代码和医生收费代码，从 DER-CA 数据库中识别出 2 型糖尿病儿童的生物母亲的糖尿病。确定母亲中糖尿病的诊断时间与妊娠的孕龄有关。
妊娠前糖尿病暴露的最佳行政定义是索引儿童的母亲在怀孕前或怀孕前 25 周内的任何糖尿病事件代码（敏感性：84.77%；阳性预测值：92%）。
可以使用引用的定义在利用行政数据的研究中定义妊娠前糖尿病暴露。
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