Institute for Cardiovascular Science and Department of Cardiovascular Surgery, Collaborative Innovation Center of Hematology, First Affiliated Hospital and Medical College of Soochow University, Soochow University, Suzhou, Jiangsu, 215123, People's Republic of China.
Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Soochow University, National Clinical Research Center for Hematologic Diseases, the First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.
J Cardiovasc Transl Res. 2022 Jun;15(3):524-534. doi: 10.1007/s12265-022-10263-8. Epub 2022 Apr 28.
Ischemic diseases are life-threatening, and the incidence increases as people's lifestyles change. Medications and surgical intervention offer limited benefit, and stem cell therapy has emerged as a potential approach for treating ischemic diseases. The exosomes secreted by stem cells have attracted more attention because they do not trigger the immune response and can be used as drug carriers. The non-coding RNA (ncRNA) carried by exosomes plays a key role in mediating exosome's beneficial effect, which can be further enhanced when combined with nanomaterials to improve its retention time. Here, we review the downstream target molecules and signal pathways of ncRNA and summarize recent advances of some nanomaterials used to encapsulate exosomes and promote ischemic tissue repair. We highlight the imprinting of exosomes from parent cells and discuss how the inflammasome pathway may be targeted for the development of novel therapy for ischemic diseases.
缺血性疾病危及生命，且随着人们生活方式的改变，其发病率呈上升趋势。药物治疗和手术干预的获益有限，而干细胞治疗已成为治疗缺血性疾病的一种潜在方法。干细胞分泌的外泌体由于不会引发免疫反应，可作为药物载体，因此受到了更多关注。外泌体所携带的非编码 RNA（ncRNA）在介导外泌体的有益作用中发挥关键作用，与纳米材料结合使用可进一步增强其保留时间。在这里，我们综述了 ncRNA 的下游靶分子和信号通路，并总结了一些用于封装外泌体并促进缺血组织修复的纳米材料的最新进展。我们重点介绍了亲本细胞中外泌体的印迹，并讨论了如何针对炎性小体途径为缺血性疾病的治疗开发新的疗法。
