Zhu Z, Mao N Y, Zhang Y, Xu W W
National Institute for Viral Diseases Control and Prevention, China CDC, NHC Key Laboratory of Medical Virology and Viral Diseases, WHO WPRO Regional Reference Measles/Rubella Laboratory, Beijing 102206, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2022 Jun 6;56(6):679-681. doi: 10.3760/cma.j.cn112150-20220427-00423.
Since January 2022, acute severe hepatitis cases with unknown etiology in children have occurred in many countries in Europe and the United States, and 43.8% of the cases were positive for human adenovirus (HAdV), and some cases were identified as HAdV-41. However, more evidences including etiology, genomics, liver pathology, and immunohistochemistry are needed to determine the main cause of this outbreak. At present, due to the lack of systematic surveillance and research on hepatitis caused by HAdV infection, it is impossible to determine whether there are similar hepatitis cases occurred in China. It is urgent to carry out HAdV virolgocial surveillance based on clinical symptom, and potential risk of acute severe hepatitis should be studied as soon as possible according to the available relevant clinical, epidemiological and virological data, as well as risk factor information, which will provide scientific and technical support for the prevention and control of HAdV-related diseases.
自2022年1月以来，欧美多个国家出现了病因不明的儿童急性重症肝炎病例，其中43.8%的病例人腺病毒（HAdV）检测呈阳性，部分病例被鉴定为HAdV-41。然而，需要更多包括病因学、基因组学、肝脏病理学和免疫组织化学等方面的证据来确定此次疫情的主要原因。目前，由于缺乏对HAdV感染所致肝炎的系统监测和研究，无法确定中国是否也出现了类似的肝炎病例。迫切需要基于临床症状开展HAdV病毒学监测，并根据现有的相关临床、流行病学和病毒学数据以及风险因素信息，尽快研究急性重症肝炎的潜在风险，这将为HAdV相关疾病的防控提供科学技术支持。
