Kallarakkal T G, Ismail S M, Goh Y C
Universiti Malaya, Faculty of Dentistry, Department of Oral and Maxillofacial Clinical Sciences, Kuala Lumpur, Malaysia.
Malays J Pathol. 2022 Apr;44(1):121-127.
Acinic cell carcinoma is an uncommon malignant salivary gland tumour accounting for approximately 6-7% of all salivary gland neoplasms. The key diagnostic feature of acinic cell carcinoma is the presence of acinar cell differentiation characterised by cytoplasmic zymogen secretory granules. This tumour shows a variety of growth patterns, including solid, microcystic, follicular and papillary cystic patterns. Acinic cell carcinoma is typically a cytologically low-grade malignancy. Acinic cell carcinomas with high-grade transformation (HGT) are exceedingly rare and are reported to have a more aggressive clinical course than conventional acinic cell carcinoma. This is a case report of this uncommon entity with high-grade transformation arising on the soft palate in a 64-year-old woman.
腺泡细胞癌是一种罕见的唾液腺恶性肿瘤，约占所有唾液腺肿瘤的6-7%。腺泡细胞癌的关键诊断特征是存在以细胞质酶原分泌颗粒为特征的腺泡细胞分化。该肿瘤表现出多种生长模式，包括实性、微囊性、滤泡性和乳头状囊性模式。腺泡细胞癌通常是一种细胞学上低级别恶性肿瘤。伴有高级别转化（HGT）的腺泡细胞癌极为罕见，据报道其临床病程比传统腺泡细胞癌更具侵袭性。本文报告了一名64岁女性软腭出现的这种伴有高级别转化的罕见病例。
