Hirokawa M, Sugihara K, Sai T, Monobe Y, Kudo H, Sano N, Sano T
Department of Pathology, University of Tokushima School of Medicine, Tokushima, Japan.
Histopathology. 2002 Mar;40(3):223-9. doi: 10.1046/j.1365-2559.2002.01346.x.
Acinic cell-like breast carcinoma is a newly recognized entity, and few acinic cell-like breast carcinoma cases have been reported. All reported acinic cell-like breast carcinomas were counterparts of the solid type of acinic cell carcinoma of the salivary gland. We report here three cases of secretory breast carcinoma with acinic cell differentiation, and discuss the similarity between secretory breast carcinoma and acinic cell carcinoma of the salivary gland.
The cases were histologically identical to acinic cell carcinoma of the salivary gland: papillary-cystic type in case 1, a mixture of papillary-cystic, microcystic and follicular type in case 2, and microfollicular type in case 3. Immunohistochemically, the tumour cells were positive for salivary-type amylase, lysozyme, S100 protein and alpha 1-antitrypsin, and negative or less reactive for gross cystic disease fluid protein-15 and oestrogen receptor. All three cases did not reveal metastasis or recurrence.
These cases were typical of secretory breast carcinoma, and were clinically, histologically and immunohistochemically analogous to acinic cell carcinoma of the salivary gland. We emphasize that secretory breast carcinoma and acinic cell carcinoma of the salivary gland may be identical lesions.
腺泡细胞样乳腺癌是一种新认识的实体，报道的腺泡细胞样乳腺癌病例很少。所有报道的腺泡细胞样乳腺癌均为涎腺实性型腺泡细胞癌的对应病变。我们在此报告3例具有腺泡细胞分化的分泌性乳腺癌病例，并讨论分泌性乳腺癌与涎腺腺泡细胞癌之间的相似性。
这些病例在组织学上与涎腺腺泡细胞癌相同：病例1为乳头囊状型，病例2为乳头囊状、微囊状和滤泡状混合型，病例3为微滤泡型。免疫组化显示，肿瘤细胞对涎腺型淀粉酶、溶菌酶、S100蛋白和α1-抗胰蛋白酶呈阳性，对巨大囊肿病液体蛋白-15和雌激素受体呈阴性或反应较弱。所有3例均未出现转移或复发。
这些病例为典型的分泌性乳腺癌，在临床、组织学和免疫组化方面与涎腺腺泡细胞癌相似。我们强调，分泌性乳腺癌与涎腺腺泡细胞癌可能是同一病变。
