缺血修饰白蛋白对急性阑尾炎的诊断价值：一项前瞻性病例对照研究。
The predictive value of ischemia-modified albumin in the diagnosis of acute appendicitis: A prospective case-control study.
机构信息
Department of General Surgery, University of Medical Sciences, Keçiören Training and Research Hospital, Ankara-Turkey.
Department of General Surgery, University of Hitit, Erol Olçok Training and Research Hospital, Çorum-Turkey.
出版信息
Ulus Travma Acil Cerrahi Derg. 2022 Apr;28(4):523-528. doi: 10.14744/tjtes.2020.58675.
BACKGROUND
Surgical planning is critical for ongoing treatment and prognosis of the disease's course after an appendicitis diag-nosis. Ischemia-modified albumin (IMA) has been used as a biomarker for a variety of ischemia-related disorders in the past. The aim of this study is to determine the IMA level in patients with AA and to evaluate its predictive significance.
METHODS
A total of 139 participants were enrolled in the trial. After diagnosis and before surgery, the amount of plasma IMA was tested. Patients diagnosed with appendicitis in Group 1 (n=97) and volunteer surgical patients not diagnosed with appendicitis in Group 2 (n=42) were compared as the final diagnostic criterion.
RESULTS
The data of 139 patients with a mean age of 36.15 were evaluated statistically. IMA values were analyzed in both groups. The mean IMA of all patients was 0.74±0.16 AbsU. When the two groups were compared, it was seen that IMA was statistically higher in Group 1 than in the control group. While the area under the curve for IMA was 0.670, the sensitivity for the cutoff value of 0.715 was 68%, the specificity was 62%.
CONCLUSION
Our study shows that IMA values provide significant results in predicting acute appendicitis.
背景
在阑尾炎诊断后，手术计划对于疾病进程的持续治疗和预后至关重要。缺血修饰白蛋白（IMA）过去曾被用作与多种缺血相关疾病的生物标志物。本研究旨在确定急性阑尾炎（AA）患者的 IMA 水平，并评估其预测意义。
方法
本试验共纳入 139 名参与者。在诊断后且手术前，检测了血浆 IMA 的量。将诊断为阑尾炎的患者分为第 1 组（n=97），诊断为阑尾炎的患者为 97 例；未诊断为阑尾炎的志愿手术患者分为第 2 组（n=42），作为最终诊断标准。
结果
对 139 名平均年龄为 36.15 岁的患者数据进行了统计学评估。对两组患者的 IMA 值进行了分析。所有患者的 IMA 平均值为 0.74±0.16 AbsU。当两组进行比较时，第 1 组的 IMA 明显高于对照组。IMA 的曲线下面积为 0.670，截断值为 0.715 时的敏感性为 68%，特异性为 62%。
结论
我们的研究表明，IMA 值在预测急性阑尾炎方面提供了显著的结果。
Zotero 插件