Emergency Department, Ajou University School of Medicine, Woncheon-dong, Yeongtong-gu, Suwon, 443-721, Republic of Korea.
Neurol Sci. 2011 Feb;32(1):133-8. doi: 10.1007/s10072-010-0457-4. Epub 2010 Dec 11.
This study was conducted to investigate whether albumin-adjusted ischemia-modified albumin index (IMA index) is more sensitive and accurate than ischemia-modified albumin (IMA) as early detection marker of ischemic stroke, and to compare IMA and IMA index in progression and non-progression of ischemic stroke. This case-control study was done at an emergency medical center of a university hospital. 52 patients with neurological symptoms were enrolled (28 Ischemic Stroke Group and 24 Non-Stroke Group). In the ROC analysis of IMA index to diagnose stroke, area under the curve (AUC) was 0.990 (cutoff value 91.4; 95% CI: 0.970-1.000; sensitivity: 96.4%; specificity 95.8%). The AUC for IMA value was 0.928 (cutoff value 98 U/ml; 95% CI 0.857-0.999; sensitivity 89.3%; specificity 88.5%). [corrected] The difference between progression (n = 12) and non-progression group (n = 16) in IMA and IMA index were statistically insignificant (p > 0.01). IMA index was more sensitive than conventional IMA value as diagnostic biomarker of stroke, however, arguable as a predictive biomarker for progression of ischemic stroke.
本研究旨在探讨白蛋白校正的缺血修饰白蛋白指数（IMA 指数）是否比缺血修饰白蛋白（IMA）作为缺血性脑卒中的早期检测标志物更敏感和准确，并比较 IMA 和 IMA 指数在缺血性脑卒中的进展和非进展中的作用。这是一项在一所大学医院的急诊医学中心进行的病例对照研究。共纳入 52 例有神经症状的患者（28 例缺血性脑卒中组和 24 例非脑卒中组）。在 IMA 指数诊断脑卒中的 ROC 分析中，曲线下面积（AUC）为 0.990（截断值 91.4；95%CI：0.970-1.000；敏感性：96.4%；特异性 95.8%）。IMA 值的 AUC 为 0.928（截断值 98 U/ml；95%CI 0.857-0.999；敏感性 89.3%；特异性 88.5%）。[校正]IMA 和 IMA 指数在进展组（n=12）和非进展组（n=16）之间的差异无统计学意义（p＞0.01）。IMA 指数作为脑卒中的诊断生物标志物比传统的 IMA 值更敏感，但作为缺血性脑卒中进展的预测生物标志物则存在争议。
