Karakılıç E, Çelikel E, Uysal P I, Topçuoğlu C, Turhan T, Özakın E
Department of Emergency Medicine, Eskisehir Osmangazi University School of Medicine, Eskişehir, Turkey.
Department of Emergency Medicine, University of Health Sciences Etlik City Hospital, Ankara, Turkey.
Niger J Clin Pract. 2023 Dec 1;26(12):1779-1783. doi: 10.4103/njcp.njcp_1862_21. Epub 2023 Dec 29.
In previous studies, it was shown that ischemia-modified albumin (IMA) is an early marker of ischemia and different pathologies. However, IMA level change is unknown in patients with peripheral vertigo. It is also known that serum albumin levels can change in some patients with peripheral vertigo and that changes in serum albumin levels affect IMA levels.
In this study, we aimed to assess IMA, albumin-adjusted IMA, and albumin levels in patients with peripheral vertigo by comparing a control group.
This prospective, case-control study included 46 patients aged 18-70 years who presented to emergency department with vertigo. Forty-nine healthy volunteers without known disease were included as controls. Serum albumin and IMA levels were measured, and albumin-adjusted IMA levels were calculated. Data were analyzed by statistical methods.
Mean age was 54.0 ± 15.7 in the patient group, whereas 43.8 ± 9.9 years in the control group. Albumin level was found to be significantly lower in patients with peripheral vertigo when compared to controls (P < 0.001). IMA level was found to be higher in the patient group compared to the controls, but it was not statistically significant (P = 0.06). However, albumin-adjusted IMA, which shows the real IMA level, was found to be higher than the control group (P = 0.02).
It was observed that IMA level was slightly higher in patients with peripheral vertigo, although not significantly, compared to the control group. However, the albumin-adjusted IMA level, which indicates the real IMA level, was observed to be higher in this group than in the control group. It was determined that the sensitivity of this test was 34%, and the specificity was 87%. Patients with peripheral vertigo had lower albumin levels compared to controls.
在先前的研究中，已表明缺血修饰白蛋白（IMA）是缺血和不同病理状态的早期标志物。然而，外周性眩晕患者的IMA水平变化尚不清楚。还已知一些外周性眩晕患者的血清白蛋白水平会发生变化，且血清白蛋白水平的变化会影响IMA水平。
在本研究中，我们旨在通过与对照组比较，评估外周性眩晕患者的IMA、白蛋白校正后的IMA和白蛋白水平。
这项前瞻性病例对照研究纳入了46名年龄在18至70岁之间因眩晕就诊于急诊科的患者。49名无已知疾病的健康志愿者作为对照。测量血清白蛋白和IMA水平，并计算白蛋白校正后的IMA水平。采用统计学方法分析数据。
患者组的平均年龄为54.0±15.7岁，而对照组为43.8±9.9岁。与对照组相比，外周性眩晕患者的白蛋白水平显著降低（P<0.001）。患者组的IMA水平高于对照组，但差异无统计学意义（P=0.06）。然而，显示真实IMA水平的白蛋白校正后的IMA高于对照组（P=0.02）。
观察到外周性眩晕患者的IMA水平虽与对照组相比略高，但无显著差异。然而，表明真实IMA水平的白蛋白校正后的IMA水平在该组中高于对照组。确定该检测的敏感性为34%，特异性为87%。外周性眩晕患者的白蛋白水平低于对照组。
