Cohen-Solal A, Beaufils P
Ann Cardiol Angeiol (Paris). 1986 Dec;35(10):633-41.
The responsibility of a thrombus and the feasibility of saving an ischemic myocardium by early revascularization explain the development of thrombolysis. Streptokinase administered intravenously rather than intracoronary restores coronary patency in 45 p. cent of the cases, improves the total and segmental left ventricular function if an early and complete revascularization is performed before the 3rd hour, helped eventually by a sequential angioplasty. At the cost of an acceptable hemorrhagic risk, thrombolysis reduces in-hospital mortality in patients under 65 years, with anterior primary infarctions. New thrombolytic agents, standardized protocols, decreased length of hospitalization and optimization of infrastructures should improve these first results.
血栓的责任以及通过早期血运重建挽救缺血心肌的可行性解释了溶栓疗法的发展。静脉注射而非冠状动脉内注射链激酶可使45%的病例恢复冠状动脉通畅，若在第3小时之前进行早期且完全的血运重建，并最终借助序贯血管成形术，可改善左心室整体和节段性功能。以可接受的出血风险为代价，溶栓疗法可降低65岁以下患有前壁原发性梗死患者的住院死亡率。新型溶栓药物、标准化方案、缩短住院时间以及优化基础设施应能改善这些初步结果。
