Health Services Research Unit, IMIM-Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain.
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Epidemiol Psychiatr Sci. 2022 Apr 29;31:e28. doi: 10.1017/S2045796022000130.
Longitudinal data on the mental health impact of the coronavirus disease 2019 (Covid-19) pandemic in healthcare workers is limited. We estimated prevalence, incidence and persistence of probable mental disorders in a cohort of Spanish healthcare workers (Covid-19 waves 1 and 2) -and identified associated risk factors.
8996 healthcare workers evaluated on 5 May-7 September 2020 (baseline) were invited to a second web-based survey (October-December 2020). Major depressive disorder (PHQ-8 ≥ 10), generalised anxiety disorder (GAD-7 ≥ 10), panic attacks, post-traumatic stress disorder (PCL-5 ≥ 7), and alcohol use disorder (CAGE-AID ≥ 2) were assessed. Distal (pre-pandemic) and proximal (pandemic) risk factors were included. We estimated the incidence of probable mental disorders (among those without disorders at baseline) and persistence (among those with disorders at baseline). Logistic regression of individual-level [odds ratios (OR)] and population-level (population attributable risk proportions) associations were estimated, adjusting by all distal risk factors, health care centre and time of baseline interview.
4809 healthcare workers participated at four months follow-up (cooperation rate = 65.7%; mean = 120 days s.d. = 22 days from baseline assessment). Follow-up prevalence of any disorder was 41.5%, (v. 45.4% at baseline, p < 0.001); incidence, 19.7% (s.e. = 1.6) and persistence, 67.7% (s.e. = 2.3). Proximal factors showing significant bivariate-adjusted associations with incidence included: work-related factors [prioritising Covid-19 patients (OR = 1.62)], stress factors [personal health-related stress (OR = 1.61)], interpersonal stress (OR = 1.53) and financial factors [significant income loss (OR = 1.37)]. Risk factors associated with persistence were largely similar.
Our study indicates that the prevalence of probable mental disorders among Spanish healthcare workers during the second wave of the Covid-19 pandemic was similarly high to that after the first wave. This was in good part due to the persistence of mental disorders detected at the baseline, but with a relevant incidence of about 1 in 5 of HCWs without mental disorders during the first wave of the Covid-19 pandemic. Health-related factors, work-related factors and interpersonal stress are important risks of persistence of mental disorders and of incidence of mental disorders. Adequately addressing these factors might have prevented a considerable amount of mental health impact of the pandemic among this vulnerable population. Addressing health-related stress, work-related factors and interpersonal stress might reduce the prevalence of these disorders substantially. Study registration number: NCT04556565.
关于 2019 年冠状病毒病(COVID-19)大流行对医护人员心理健康影响的纵向数据有限。我们估计了西班牙医护人员(COVID-19 波 1 和 2)队列中可能存在的精神障碍的患病率、发病率和持续性,并确定了相关的危险因素。
2020 年 5 月 5 日至 9 月 7 日(基线)评估的 8996 名医护人员被邀请参加第二次基于网络的调查(2020 年 10 月至 12 月)。评估了主要抑郁障碍(PHQ-8≥10)、广泛性焦虑障碍(GAD-7≥10)、惊恐发作、创伤后应激障碍(PCL-5≥7)和酒精使用障碍(CAGE-AID≥2)。包括远端(大流行前)和近端(大流行期间)危险因素。我们估计了可能患有精神障碍(基线时无障碍者)的发病率和持续性(基线时患有障碍者)。使用个体水平[比值比(OR)]和人群水平(人群归因风险比例)的逻辑回归进行估计,调整了所有远端危险因素、医疗中心和基线访谈时间。
4809 名医护人员在四个月后(合作率=65.7%;平均=120 天,标准差=22 天)参加了随访。任何疾病的随访患病率为 41.5%(基线时为 45.4%,p<0.001);发病率为 19.7%(s.e.=1.6),持续性为 67.7%(s.e.=2.3)。与发病率有显著双变量调整关联的近端因素包括:与工作相关的因素[优先考虑 COVID-19 患者(OR=1.62)]、压力因素[个人健康相关压力(OR=1.61)]、人际压力(OR=1.53)和经济因素[收入显著损失(OR=1.37)]。与持续性相关的危险因素基本相似。
我们的研究表明,西班牙医护人员在 COVID-19 大流行第二波期间的精神障碍患病率与第一波相似。这在很大程度上是由于基线时检测到的精神障碍的持续存在,但在 COVID-19 大流行第一波期间,没有精神障碍的 HCW 中,约有 1/5 的人出现了精神障碍的发病率。与健康相关的因素、与工作相关的因素和人际压力是精神障碍持续性和精神障碍发病率的重要风险因素。充分解决这些因素可能会防止这一脆弱人群在大流行中遭受相当大的心理健康影响。解决与健康相关的压力、与工作相关的因素和人际压力可能会大大降低这些疾病的患病率。研究注册编号:NCT04556565。