在太平洋和北极地区，缺乏 IFNAR1 和 IFNAR2 等位基因的情况出人意料地普遍。
Null IFNAR1 and IFNAR2 alleles are surprisingly common in the Pacific and Arctic.
机构信息
Department of Pediatrics, University Hospitals Leuven, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium.
出版信息
J Exp Med. 2022 Jun 6;219(6). doi: 10.1084/jem.20220491. Epub 2022 Apr 29.
In this issue of JEM, Bastard et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20220028) show that a loss-of-function IFNAR1 allele is common in western Polynesians, while Duncan et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20212427) report that a loss-of-function IFNAR2 allele is common in Inuits. Homozygotes lack type I IFN immunity but are selectively vulnerable to influenza, COVID-19 pneumonia, and complications of live-attenuated viral vaccines.
在本期《实验医学杂志》中，Bastard 等人（2022. J. Exp. Med. https://doi.org/10.1084/jem.20220028）表明，失能 IFNAR1 等位基因在西太平洋波利尼西亚人中很常见，而 Duncan 等人（2022. J. Exp. Med. https://doi.org/10.1084/jem.20212427）则报告称，失能 IFNAR2 等位基因在因纽特人中很常见。纯合子缺乏 I 型 IFN 免疫，但对流感、COVID-19 肺炎和减毒活病毒疫苗的并发症特别脆弱。
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