特应性疾病与史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症患者急性眼部和全身结局的关系。
Relationship between Atopic Disease and Acute Ocular and Systemic Outcomes in Patients with Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.
机构信息
Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Massachusetts Eye and Ear, Boston, Massachusetts, USA.
Department of Ophthalmology, Loma Linda University Medical Center, Loma Linda, California, USA.
出版信息
Ocul Immunol Inflamm. 2023 Jul;31(5):900-904. doi: 10.1080/09273948.2022.2061520. Epub 2022 Apr 29.
OBJECTIVE
To describe the relationship between history of atopic disease on systemic and ocular manifestations of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN).
METHODS
Retrospective chart review of patients with SJS/TEN patients. Those with and without prior atopic diagnosis were compared.
RESULTS
In total, 200 patients with SJS/TEN were identified. A total of 23 patients also had an atopic diagnosis. Four, 10, and 18 had atopic dermatitis, allergic rhinitis, and asthma respectively. Acute ocular severity was significantly worse in the atopic cohort. No significant differences in overall systemic severity of SJS or mortality were found between the atopic and non-atopic cohorts. Compared to our hospital system's general population, prevalence of an atopic diagnosis was significantly higher in those with SJS/TEN.
CONCLUSION
Patients with a history of an atopic diagnosis appear to have more significant acute ocular involvement during their SJS/TEN hospitalization. Atopic conditions appear to occur more frequently in the SJS/TEN population compared to the general population.
目的
描述特应性疾病史与史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症（SJS/TEN）全身和眼部表现之间的关系。
方法
对 SJS/TEN 患者进行回顾性图表审查。比较有和没有特应性诊断的患者。
结果
共确定了 200 例 SJS/TEN 患者。共有 23 例患者也有特应性诊断。分别有 4 例、10 例和 18 例患有特应性皮炎、过敏性鼻炎和哮喘。特应性组的急性眼部严重程度明显更严重。特应性组和非特应性组之间 SJS 的总体全身严重程度或死亡率无显著差异。与我们医院系统的一般人群相比，SJS/TEN 患者的特应性诊断患病率明显更高。
结论
有特应性诊断史的患者在 SJS/TEN 住院期间似乎有更明显的急性眼部受累。与一般人群相比，特应性疾病在 SJS/TEN 人群中更常见。
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