Matsui Takaaki
Division of Biological Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
Curr Opin Cell Biol. 2022 Jun;76:102083. doi: 10.1016/j.ceb.2022.102083. Epub 2022 Apr 26.
Oncogenically transformed or apoptotic cells are removed from epithelial sheets by cell-cell communication between the transformed/apoptotic cells (extruding cells) and the nearest neighboring cells. Cell extrusion is driven by actomyosin contraction and lamellipodial crawling of the nearest neighboring cells. Recent studies have found that distal cell communication also plays a role in cell extrusion. Specifically, distal cells located 3-16 cells away from the extruding cell are coordinated by calcium waves and collectively migrate toward the extruding cell to initiate cell extrusion. Here, I describe how calcium waves are generated and contribute to the extrusion of cells in mammals and zebrafish.
致癌转化或凋亡的细胞通过转化/凋亡细胞（挤出细胞）与最邻近细胞之间的细胞间通讯从上皮层中被清除。细胞挤出由最邻近细胞的肌动球蛋白收缩和片状伪足爬行驱动。最近的研究发现，远端细胞通讯在细胞挤出中也起作用。具体而言，距离挤出细胞3 - 16个细胞的远端细胞通过钙波协调，并集体朝着挤出细胞迁移以启动细胞挤出。在此，我描述了钙波是如何产生的以及如何促进哺乳动物和斑马鱼中细胞的挤出。
