推进针对癌症的自然杀伤细胞疗法。
Advancing natural killer therapies against cancer.
机构信息
Aix Marseille Univ, CNRS, INSERM, CIML, Marseille, France.
Aix Marseille Univ, CNRS, INSERM, CIML, Marseille, France; Innate Pharma Research Laboratories, Innate Pharma, Marseille, France; APHM, Hôpital de la Timone, Marseille-Immunopôle, Marseille, France.
出版信息
Cell. 2022 Apr 28;185(9):1451-1454. doi: 10.1016/j.cell.2022.04.006.
Natural killer (NK)-based therapies against cancer are emerging, but the understanding of NK cell functions needs to be completed to optimize these treatments. In this issue, Pan et al. (2022) show that pro-apoptotic molecules, such as BH3-mimetics, synergize with NK cells to induce mitochondria-driven apoptosis in tumor cells, thereby enhancing the efficacy of NK cell therapies.
基于自然杀伤 (NK) 细胞的癌症疗法正在兴起，但为了优化这些治疗方法，需要进一步了解 NK 细胞的功能。在本期杂志中，Pan 等人（2022 年）表明，促凋亡分子（如 BH3 模拟物）与 NK 细胞协同作用，诱导肿瘤细胞线粒体驱动的细胞凋亡，从而增强 NK 细胞疗法的疗效。
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