Department of Pediatrics/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu, China.
Department of Pediatrics, School of Clinical Medicine & the First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Front Immunol. 2024 Oct 2;15:1456891. doi: 10.3389/fimmu.2024.1456891. eCollection 2024.
Methyltransferase-like 3(METTL3), recognized as the primary N-methyladenosine methyltransferase, influences cellular functions such as proliferation, migration, invasion, differentiation, and fate determination by regulating gene expression post-transcriptionally. Recent studies have highlighted the indispensability of METTL3 in various immune cells such as hematopoietic stem/progenitor cells, innate immune cells (monocytes, macrophages, dendritic cells), and adaptive immune cells (thymic epithelial cell, T cells, natural killer cells). However, a comprehensive summary and analysis of these findings to elucidate the relationship between METTL3 and the immune system is yet to be undertaken. Therefore, in this review, we systematically collate reports detailing the mechanism underlying the role of METTL3 in regulating various immune processes and examine the modification of METTL3 and its potential implications. This review suggests that METTL3 plays an essential role in the immune system, ranging from maintaining homeostasis to regulating functions. Collectively, this review provides a comprehensive analysis of the relationship between METTL3 and the immune system, serving convenient researchers to understand the frontiers of immunological research and facilitate future clinical applications.
甲基转移酶样蛋白 3（METTL3），作为主要的 N6-甲基腺苷甲基转移酶，通过转录后调控基因表达来影响细胞功能，如增殖、迁移、侵袭、分化和命运决定。最近的研究强调了 METTL3 在各种免疫细胞中的不可或缺性，如造血干细胞/祖细胞、固有免疫细胞（单核细胞、巨噬细胞、树突状细胞）和适应性免疫细胞（胸腺上皮细胞、T 细胞、自然杀伤细胞）。然而，为了阐明 METTL3 与免疫系统之间的关系，还需要对这些发现进行全面总结和分析。因此，在这篇综述中，我们系统地整理了详细描述 METTL3 在调节各种免疫过程中作用机制的报告，并研究了 METTL3 的修饰及其潜在意义。本综述表明，METTL3 在免疫系统中发挥着重要作用，从维持内稳态到调节功能。总之，本综述对 METTL3 与免疫系统之间的关系进行了全面分析，为研究人员提供了方便，以了解免疫研究的前沿领域，并促进未来的临床应用。
