Aikenhead Centre for Medical Discovery, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC 3010, Australia.
Department of Politics, Media, and Philosophy, La Trobe University, Bundoora, VIC 3086, Australia.
Stem Cell Reports. 2022 May 10;17(5):1023-1032. doi: 10.1016/j.stemcr.2022.04.002. Epub 2022 Apr 28.
Stem-cell-derived tissue models generated from sick people are being used to understand human development and disease, drug development, and drug screening. However, it is possible to detect disease phenotypes before a patient displays symptoms, allowing for their use as a disease screening tool. This raises numerous issues, some of which can be addressed using similar approaches from genetic screenings, while others are unique. One issue is the relationship between disease disposition, biomarker detection, and patient symptoms and how tissue models could be used to define disease. Other issues include decisions of when to screen, what diseases to screen for, and what treatment options should be offered.
利用源自病人的干细胞衍生组织模型来理解人类发育和疾病、药物研发和药物筛选。然而，在病人出现症状之前，可以检测到疾病表型，从而将其用作疾病筛选工具。这引发了众多问题，其中一些可以使用遗传筛选的类似方法来解决，而另一些则是独特的。一个问题是疾病易感性、生物标志物检测与病人症状之间的关系，以及组织模型如何用于定义疾病。其他问题包括何时进行筛选、筛选哪些疾病以及应提供哪些治疗选择。
