局部嵌合抗原受体 T 细胞治疗：实体瘤全身性免疫的点火钥匙。
Regional CAR T cell therapy: An ignition key for systemic immunity in solid tumors.
机构信息
Department of Surgical Oncology and Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.
Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
出版信息
Cancer Cell. 2022 Jun 13;40(6):569-574. doi: 10.1016/j.ccell.2022.04.006. Epub 2022 Apr 28.
Abstract
The success of chimeric antigen receptor (CAR) T cell therapy in solid tumors, unlike in hematologic malignancies, is limited by inadequate tumor infiltration and T cell dysfunction and exhaustion. Regional delivery of CAR T cells in patients with solid tumors is safe and feasible; promotes infiltration, proliferation, and trafficking; and ignites functionally persisting systemic immunity.
摘要
嵌合抗原受体 (CAR) T 细胞疗法在实体瘤中的成功，与血液恶性肿瘤不同，受到肿瘤浸润不足以及 T 细胞功能障碍和衰竭的限制。在实体瘤患者中进行 CAR T 细胞的区域性递送是安全且可行的；促进浸润、增殖和迁移；并引发具有功能持续性的全身免疫。
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