European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Institute for Cancer Genetics, Columbia University, New York, NY.
Exp Hematol. 2022 Jul;111:25-31. doi: 10.1016/j.exphem.2022.04.006. Epub 2022 Apr 27.
Post-transcriptional RNA modifications determine RNA fate by influencing numerous processes such as translation, decay and localization. One of the most abundant RNA modifications is N-methyladenoside (mA), which has been shown to be important in healthy as well as malignant hematopoiesis. Several proteins representing key players in mA RNA biology, such as mA writers, erasers and readers, were recently reported to be essential for hematopoietic stem cell (HSC) function. In leukemia, expression of mA regulators has been shown to be increased, opening up potential opportunities for therapeutic exploitation by targeting them in blood malignancies. These recent discoveries were the focus of the Fall 2021 International Society for Experimental Hematology New Investigators webinar. We review here the latest findings in the field of mRNA modifications in normal and malignant hematopoiesis and how this might open up novel therapeutic options.
转录后 RNA 修饰通过影响翻译、降解和定位等众多过程来决定 RNA 的命运。最丰富的 RNA 修饰之一是 N6-甲基腺苷（m6A），它已被证明在健康和恶性造血中都很重要。最近有报道称，代表 m6A RNA 生物学关键因子的几种蛋白质，如 m6A 写入器、擦除器和读取器，对造血干细胞（HSC）功能至关重要。在白血病中，m6A 调节因子的表达增加，为通过靶向血液恶性肿瘤中的这些因子来进行治疗提供了潜在的机会。这些最近的发现是 2021 年秋季国际实验血液学会新研究员网络研讨会的重点。我们在这里回顾了正常和恶性造血中 mRNA 修饰的最新发现，以及这可能为新的治疗选择开辟途径。
