Stem Cell Program and Division of Hematology/Oncology, Department of Medicine, Children's Hospital Boston, Harvard Stem Cell Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA.
Stem Cell Program and Division of Hematology/Oncology, Department of Medicine, Children's Hospital Boston, Harvard Stem Cell Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA.
Exp Hematol. 2024 Oct;138:104279. doi: 10.1016/j.exphem.2024.104279. Epub 2024 Jul 14.
Blood development and regeneration require rapid turnover of cells, and ribonucleic acid (RNA) modifications play a key role in it via regulating stemness and cell fate regulation. RNA modifications affect gene activity via posttranscriptional and translation-mediated mechanisms. Diverse molecular players involved in RNA-modification processes are abundantly expressed by hematopoietic stem cells and lineages. Close to 150 RNA chemical modifications have been reported, but only N6-methyl adenosine (mA), inosine (I), pseudouridine (Ψ), and m1A-a handful-have been studied in-cell fate regulation. The role of RNA modification in blood diseases and disorders is an emerging field and offers potential for therapeutic interventions. Knowledge of RNA-modification and enzymatic activities could be used to design therapies in the future. Here, we summarized the recent advances in RNA modification and the epitranscriptome field and discussed their regulation of blood development and regeneration.
血液的发育和再生需要细胞的快速周转，而核糖核酸 (RNA) 修饰通过调节干性和细胞命运调节在其中发挥关键作用。RNA 修饰通过转录后和翻译介导的机制影响基因活性。参与 RNA 修饰过程的多种分子均在造血干细胞及其谱系中大量表达。已报道了近 150 种 RNA 化学修饰，但仅有 N6-甲基腺苷 (m6A)、肌苷 (I)、假尿嘧啶 (Ψ) 和 m1A——少数几种——在细胞命运调节中得到了研究。RNA 修饰在血液疾病和紊乱中的作用是一个新兴领域，为治疗干预提供了潜力。对 RNA 修饰和酶活性的了解可用于未来设计疗法。在这里，我们总结了 RNA 修饰和表观转录组领域的最新进展，并讨论了它们对血液发育和再生的调控。
