Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang 110004, People's Republic of China.
Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang 110004, People's Republic of China; Clinical Skills Practice Teaching Center, Shengjing Hospital of China Medical University, Shenyang 110004, People's Republic of China.
Diabetes Res Clin Pract. 2022 May;187:109882. doi: 10.1016/j.diabres.2022.109882. Epub 2022 Apr 26.
Poor wound healing can seriously affect the health of patients with diabetes and result in a heavy medical burden. Recently, exosomes have been considered the key substances involved in the healing of diabetic wounds. The important cells related to the process of diabetic wound healing include endothelial cells (ECs), fibroblasts, macrophages, and keratinocytes. Accumulating evidence indicates that exosomes participate in intercellular communication by regulating the expression of biologically functional molecules and modulating the aforementioned cells through various pathways, thereby promoting angiogenesis, collagen synthesis as well as inhibiting inflammation. This article reviews the mechanism of exosomes in the aforementioned cells and their role in diabetic wound healing. This review further discusses the combined use of exosomes and hydrogels or dressings to prolong the residence time of exosomes in wounds. A better understanding of the mechanism through which exosomes participate in wound healing in diabetes and its impact on the wound healing process may provide insights into the future treatment of diabetic wounds.
伤口愈合不良会严重影响糖尿病患者的健康，并导致沉重的医疗负担。最近，外泌体被认为是参与糖尿病创面愈合的关键物质。与糖尿病创面愈合过程相关的重要细胞包括内皮细胞（ECs）、成纤维细胞、巨噬细胞和角质形成细胞。越来越多的证据表明，外泌体通过调节具有生物学功能的分子的表达，并通过各种途径调节上述细胞，从而促进血管生成、胶原合成和抑制炎症，参与细胞间通讯。本文综述了外泌体在上述细胞中的作用及其在糖尿病创面愈合中的作用。本文还进一步探讨了外泌体与水凝胶或敷料联合使用以延长外泌体在伤口中的驻留时间。更好地了解外泌体参与糖尿病创面愈合的机制及其对创面愈合过程的影响，可能为糖尿病创面的未来治疗提供新的思路。
