Truong Emily, Noureddin Mazen
Department of Medicine, 8700 Beverly Boulevard, #5512, Los Angeles, CA 90048, USA; Cedars-Sinai Medical Center, 8900 Beverly Boulevard, Los Angeles, CA 90048, USA.
Department of Medicine, Karsh Division of Gastroenterology and Hepatology, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Cedars-Sinai Fatty Liver Program, Division of Digestive and Liver Diseases, Department of Medicine, Comprehensive Transplant Center, Cedars-Sinai Medical Center, 8900 Beverly Boulevard, Los Angeles, CA 90048, USA.
Clin Liver Dis. 2022 May;26(2):213-227. doi: 10.1016/j.cld.2022.01.008. Epub 2022 Apr 1.
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, involving approximately 25% of the general population and increasing in prevalence in patient populations afflicted with metabolic syndrome and type 2 diabetes. This article discusses the complex interplay between NAFLD and chronic kidney disease (CKD), as well as the underlying pathogenesis and mechanisms through which NAFLD and CKD are linked. Exploration of these sophisticated relationships and causative factors is essential to accurately assessing kidney function in patients with NAFLD, recommending pharmacologic treatment of disease, and identifying favorable avenues for future investigation.
非酒精性脂肪性肝病（NAFLD）是全球慢性肝病最常见的病因，约涉及25%的普通人群，且在患有代谢综合征和2型糖尿病的患者群体中患病率不断上升。本文讨论了NAFLD与慢性肾脏病（CKD）之间的复杂相互作用，以及NAFLD与CKD相关联的潜在发病机制和原理。探究这些复杂的关系和致病因素对于准确评估NAFLD患者的肾功能、推荐疾病的药物治疗以及确定未来研究的有利途径至关重要。
