School of Human Development and Health, University of Southampton Faculty of Medicine, Southampton, UK
Department of Obstetrics and Gynaecology, Princess Anne Hospital, Southampton, UK.
BMJ Open. 2022 Apr 29;12(4):e058419. doi: 10.1136/bmjopen-2021-058419.
The study aims to determine the relative importance of key attributes of a novel intrauterine device. The device monitors uterine oxygen, pH and temperature in real time with the aim of improving our understanding and treatment of reproductive disorders.
A discrete choice experiment was used to elicit preferences in this novel investigative tool. The attributes and levels used in the choice scenarios were length of time using the device (7, 14 or 28 days), information obtained to guide treatment (limited, majority or all cases), risk of complications (1% or 10%) and discreteness (completely discrete, moderately discrete or indiscrete).
Secondary care hospital in Hampshire, UK.
361 women of reproductive age.
Conditional logit and latent class logit regression models to determine the preference for each attribute.
Conditional logit coefficients allow comparison between attributes; women placed most importance on obtaining information to guide treatment in all cases (2.771), followed by having a completely discrete device (1.104), reducing risk of complications by 1% (0.184) and decreased length of time by 1 day (0.0150). All coefficients p<0.01. Latent class conditional logit assigns participants to two classes with 27.4% in class 1 who are less likely to have higher education or qualify for National Health Service-funded in vitro fertilisation compared with class 2. Those in class 2 placed 1.7 times more importance on a device whose information guided treatment in all cases and a 1% decrease in complications risk was nearly 15 times more attractive.
Women placed most importance on having a device that obtains information to guide treatment and are willing to use the device for a longer, have a device with higher risk of complications and an indiscrete device if it is able to provide answers and direction for treatment of their reproductive disorder.
本研究旨在确定一种新型宫内节育器关键属性的相对重要性。该器械实时监测子宫的氧气、pH 值和温度，旨在增进我们对生殖障碍的理解并改善其治疗效果。
采用离散选择实验来评估该新型研究工具的偏好。选择情景中使用的属性和水平包括使用器械的时间长度（7、14 或 28 天）、指导治疗的获得信息（有限、多数或所有病例）、并发症风险（1%或 10%）和离散度（完全离散、中度离散或不离散）。
英国汉普郡的二级保健医院。
361 名育龄妇女。
条件逻辑回归和潜在类别逻辑回归模型来确定对每个属性的偏好。
条件逻辑回归系数可用于比较属性；女性最看重所有病例中获得指导治疗的信息（2.771），其次是完全离散的器械（1.104）、降低 1%的并发症风险（0.184）和减少 1 天的使用时间（0.0150）。所有系数 p<0.01。潜在类别条件逻辑回归将参与者分配到两个类别，其中 27.4%的参与者属于类别 1，与类别 2 相比，类别 1 的参与者不太可能接受过高等教育或有资格获得国家卫生服务机构资助的体外受精。类别 2 的参与者更看重一种器械，该器械在所有病例中都能提供指导治疗的信息，降低 1%的并发症风险的吸引力是近 15 倍。
女性最看重获得能够指导治疗的器械，并愿意使用更长时间、风险更高的器械，以及完全不离散的器械，如果它能够为生殖障碍的治疗提供答案和指导。
