Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Hiroshima Heiwa Clinic, Hiroshima, Japan.
J Nucl Cardiol. 2023 Jun;30(3):1158-1165. doi: 10.1007/s12350-022-02975-w. Epub 2022 Apr 29.
How coronary arterial F-sodium fluoride (F-NaF) uptake on positron emission tomography changes over the long term and what clinical factors impact the changes remain unclear. We sought to investigate the topics in this study.
We retrospectively studied 15 patients with ≥1 coronary atherosclerotic lesion/s detected on cardiac computed tomography who underwent baseline and follow-up (interval of >3 years) F-NaF positron emission tomography/computed tomography scans. Focal F-NaF uptake in each lesion was quantified using maximum tissue-to-background ratio (TBR). The temporal change in TBR was assessed using a ratio of follow-up to baseline TBR (R-TBR).
A total of 51 lesions were analyzed. Mean R-TBR was 0.96 ± 0.21. CT-based lesion features (location, obstructive stenosis, plaque types, features of high-risk plaque) did not correlate with an increase in R-TBR. In multivariate analysis, baseline TBR significantly correlated with higher follow-up TBR (β = 0.57, P < 0.0001), and the presence of diabetes mellitus significantly correlated with both higher follow-up TBR (β = 0.34, P = 0.001) and elevated R-TBR (β = 0.40, P = 0.003).
Higher coronary arterial F-NaF uptake is likely to remain continuously high. Diabetes mellitus affects the long-term increase in coronary arterial F-NaF uptake.
氟[F]-氟化钠（F-NaF）在冠状动脉的摄取在长期内如何变化，以及哪些临床因素影响这种变化尚不清楚。本研究旨在探讨这些问题。
我们回顾性研究了 15 例至少有 1 个在心脏 CT 上检测到的冠状动脉粥样硬化病变/节段的患者，这些患者进行了基线和随访（间隔>3 年）F-NaF 正电子发射断层扫描/计算机断层扫描检查。使用最大组织与背景比（TBR）对每个病变的局灶性 F-NaF 摄取进行定量。通过比较随访和基线 TBR 的比值（R-TBR）来评估 TBR 的时间变化。
共分析了 51 个病变。平均 R-TBR 为 0.96±0.21。基于 CT 的病变特征（位置、阻塞性狭窄、斑块类型、高危斑块特征）与 R-TBR 的增加无关。多变量分析显示，基线 TBR 与较高的随访 TBR显著相关（β=0.57，P<0.0001），而糖尿病的存在与较高的随访 TBR（β=0.34，P=0.001）和 R-TBR 的升高（β=0.40，P=0.003）均显著相关。
冠状动脉 F-NaF 的摄取可能会持续升高。糖尿病会影响冠状动脉 F-NaF 摄取的长期增加。
