Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
J Nucl Cardiol. 2021 Dec;28(6):2700-2705. doi: 10.1007/s12350-020-02099-z. Epub 2020 Mar 17.
The goal of this study was to investigate the potential determinants of F-NaF uptake in femoral arteries as a marker of arterial calcification in patients with type 2 diabetes and a history of arterial disease.
The study consisted of participants of a randomized controlled trial to investigate the effect of vitamin K2 (NCT02839044). In this prespecified analysis, subjects with type 2 diabetes and known arterial disease underwent full body F-NaF PET/CT. Target-to-background ratio (TBR) was calculated by dividing the mean SUV from both superficial femoral arteries by the SUV in the superior vena cava (SVC) and calcium mass was measured on CT. The association between F-NaF TBR and cardiovascular risk factors was investigated using uni- and multivariate linear regression corrected for age and sex. In total, 68 patients (mean age: 69 ± 8 years; male: 52) underwent F-NaF PET/CT. Higher CT calcium mass, total cholesterol, and HbA1c were associated with higher F-NaF TBR after adjusting.
This study shows that several modifiable cardiovascular risk factors (total cholesterol, triglycerides, HbA1c) are associated with femoral F-NaF tracer uptake in patients with type 2 diabetes.
本研究旨在探讨 2 型糖尿病合并动脉疾病病史患者股动脉 F-NaF 摄取作为动脉钙化标志物的潜在决定因素。
该研究纳入了一项随机对照试验的参与者，以研究维生素 K2 的效果（NCT02839044）。在这项预设分析中，患有 2 型糖尿病和已知动脉疾病的患者接受了全身 F-NaF PET/CT 检查。通过将双侧股浅动脉的平均 SUV 除以上腔静脉（SVC）的 SUV 来计算目标与背景比（TBR），并在 CT 上测量钙质量。使用单变量和多变量线性回归校正年龄和性别，研究 F-NaF TBR 与心血管危险因素之间的关系。共 68 例患者（平均年龄：69±8 岁；男性：52）接受了 F-NaF PET/CT 检查。校正后，CT 钙质量、总胆固醇和 HbA1c 较高与 F-NaF TBR 较高相关。
本研究表明，一些可改变的心血管危险因素（总胆固醇、甘油三酯、HbA1c）与 2 型糖尿病患者股动脉 F-NaF 示踪剂摄取有关。
