Department of Surgery, Ystad Hospital, Ystad, Sweden.
Institute of Clinical Sciences, Lund University, Lund, Sweden.
J Neuroendocrinol. 2022 Jun;34(6):e13139. doi: 10.1111/jne.13139. Epub 2022 Apr 29.
For patients with gastroenteropancreatic neuroendocrine tumours (GEP-NET), health-related quality of life (HRQoL) is important. Meanwhile, whether tumour volume is associated with HRQoL is unknown. Hence, the aim of this study was to assess if total somatostatin receptor expressing tumour volume is correlated with HRQoL in patients with metastatic GEP-NET. Some 71 patients were included in the study. HRQoL and NET-specific symptoms were assessed with EORTC QLQ-C30 and EORTC GI.NET21. A summary score was calculated from the output of the QLQ-C30. Total somatostatin receptor expressing tumour volume was retrospectively evaluated on somatostatin receptor imaging with positron emission tomography-computed tomography ( Ga-DOTA-TATE/TOC PET-CT) in each patient. Simple and multiple linear regression were used to evaluate the correlation between tumour volume and HRQoL, controlling for potential confounders. No correlation was found between total somatostatin receptor expressing tumour volume and QLQ-C30 summary score. Weak positive correlations were found between total tumour volume and the specific symptoms dyspnoea, diarrhoea and flushing. To the best of our knowledge, this is the first study to evaluate the association between total somatostatin expressing tumour volume and HRQoL. Our results indicate that, while tumour volume is weakly associated with symptom severity of the carcinoid syndrome, other factors might impact more on overall HRQoL.
对于患有胃肠胰神经内分泌肿瘤（GEP-NET）的患者，健康相关生活质量（HRQoL）很重要。同时，肿瘤体积是否与 HRQoL 相关尚不清楚。因此，本研究旨在评估转移性 GEP-NET 患者中总生长抑素受体表达肿瘤体积是否与 HRQoL 相关。本研究纳入了 71 名患者。采用 EORTC QLQ-C30 和 EORTC GI.NET21 评估 HRQoL 和 NET 特异性症状。从 QLQ-C30 的输出中计算出综合评分。在每位患者的生长抑素受体成像中，采用正电子发射断层扫描-计算机断层扫描（Ga-DOTA-TATE/TOC PET-CT）回顾性评估总生长抑素受体表达肿瘤体积。采用简单和多元线性回归来评估肿瘤体积与 HRQoL 之间的相关性，同时控制潜在的混杂因素。总生长抑素受体表达肿瘤体积与 QLQ-C30 综合评分之间无相关性。总肿瘤体积与呼吸困难、腹泻和潮红等特定症状之间存在弱正相关。据我们所知，这是第一项评估总生长抑素表达肿瘤体积与 HRQoL 之间关联的研究。我们的研究结果表明，尽管肿瘤体积与类癌综合征的症状严重程度呈弱相关，但其他因素可能对整体 HRQoL 产生更大影响。
